Trial reportPsychiatric services (Washington, D.C.)2019
Cost-Effectiveness of Preventing Depression Among At-Risk Youths: Postintervention and 2-Year Follow-Up.
Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Psychiatric services (Washington, D.C.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Cost-effectiveness evidence of mental health prevention and promotion interventions: A systematic review of economic evaluations.PLoS medicine · 2021Pooled it
- Cost-effectiveness of a transdiagnostic psychotherapy program for youth with common mental health problems.BMC health services research · 2022Trial
- Cost-effectiveness of Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care.JAMA network open · 2021Trial
- Effects of an adolescent depression prevention program on maternal criticisms and positive remarks.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2020Trial
- Did national implementation of interpersonal counseling improve adolescent depression treatment pathways in primary care? Protocol for a longitudinal cohort study.BMC public health · 2026Article
- Article
- Cost-utility analysis of school-based depression prevention interventions for Thai adolescents with subsyndromal depression.BMC psychiatry · 2025Article
- Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care.JAMA health forum · 2025Article
- A Randomized Clinical Trial of Technology-Enhanced Family-Focused Therapy for Youth in the Early Stages of Mood Disorders.JAACAP open · 2023Article
- School-based socio-emotional learning programs to prevent depression, anxiety and suicide among adolescents: a global cost-effectiveness analysis.Epidemiology and psychiatric sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Frances L LynchCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
John F DickersonCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Gregory N ClarkeCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
William R BeardsleeCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
V Robin WeersingCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Tracy R G GladstoneCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Giovanna PortaCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
David A BrentCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Tami L MarkCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Lynn L DeBarCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Steven D HollonCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Judy GarberCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Lynch, Dickerson, Clarke, DeBar); Judge Baker Children's Center, Harvard University, Boston (Beardslee); San Diego State University (SDSU)-University of California, San Diego, Joint Doctoral Program in Clinical Psychology, SDSU, San Diego (Weersing); Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts (Gladstone); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Porta); Department of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh (Brent); Behavioral Health Financing, RTI International, Research Triangle Park, North Carolina (Mark); Department of Psychology (Hollon) and Department of Psychiatry (Garber), Vanderbilt University, Nashville, Tennessee.
Wellesley Centers for Women · US
Funding
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPrevention of Depression in At-Risk AdolescentsR01MH064503 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRENT, DAVID A. · 2003 to 2012
$3.9MPrevention of Depression (POD)R01MH064541 · NIMH · KAISER FOUNDATION RESEARCH INSTITUTE · PI CLARKE, GREGORY N · 2003 to 2012
$3.6MPrevention of Depression in At-Risk-AdolescentsR01MH064735 · NIMH · VANDERBILT UNIVERSITY · PI GARBER, JUDY · 2003 to 2012
$3.2MPrevention of Depression in At-Risk AdolescentsR01MH064717 · NIMH · JUDGE BAKER CHILDREN'S CENTER · PI BEARDSLEE, WILLIAM R., GLADSTONE, TRACY G · 2003 to 2012
$2.8MNCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NIMH NIH HHS R01 MH064503NIMH NIH HHS R01 MH064541NIMH NIH HHS R01 MH064717NIMH NIH HHS R01 MH064735
Abstract
objectiveYouth depression can be prevented, yet few programs are offered. Decision makers lack cost information. This study evaluated the cost-effectiveness of a cognitive-behavioral prevention program (CBP) versus usual care.
methodsA cost-effectiveness analysis was conducted with data from a randomized controlled trial of 316 youths, ages 13-17, randomly assigned to CBP or usual care. Youths were at risk of depression because of a prior depressive disorder or subthreshold depressive symptoms, or both, and had parents with a prior or current depressive disorder. Outcomes included depression-free days (DFDs), quality-adjusted life years (QALYs), and costs.
resultsNine months after baseline assessment, youths in CBP experienced 12 more DFDs (p=.020) and .018 more QALYs (p=.007), compared with youths in usual care, with an incremental cost-effectiveness ratio (ICER) of $24,558 per QALY. For youths whose parents were not depressed at baseline, CBP youths had 26 more DFDs (p=.001), compared with those in usual care (ICER=$10,498 per QALY). At 33 months postbaseline, youths in CBP had 40 more DFDs (p=.05) (ICER=$12,787 per QALY). At 33 months, CBP youths whose parents were not depressed at baseline had 91 more DFDs (p=.001) (ICER=$13,620 per QALY). For youths with a currently depressed parent at baseline, CBP was not significantly more effective than usual care at either 9 or 33 months, and costs were higher.
conclusionsCBP produced significantly better outcomes than usual care and was particularly cost-effective for youths whose parents were not depressed at baseline. Depression prevention programs could improve youths' health at a reasonable cost; services to treat depressed parents may also be warranted.
Indexed as
AdolescentChild of Impaired ParentsCognitive Behavioral TherapyCost-Benefit AnalysisDepressive DisorderFemaleFollow-Up StudiesHumansMaleParentsQuality-Adjusted Life YearsRegression AnalysisRiskUnited StatesAdolescents/adolescenceCost-effectiveness analysisDepressionPrevention
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