Evidence map›Paper›PMID 30929447›Full record

ArticleACS chemical neuroscience2019

N-Methyl-4-phenylpyridinium Scaffold-Containing Lipophilic Compounds Are Potent Complex I Inhibitors and Selective Dopaminergic Toxins.

Bryan Lickteig, Virangika K Wimalasena, Kandatege Wimalasena

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Chemical research in toxicology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bryan LickteigDepartment of Chemistry , Wichita State University , Wichita , Kansas 67260 , United States.
Virangika K WimalasenaDepartment of Chemistry , Wichita State University , Wichita , Kansas 67260 , United States.
Kandatege WimalasenaDepartment of Chemistry , Wichita State University , Wichita , Kansas 67260 , United States.ORCID 0000-0001-6419-106X

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUSHINGTON, GERALD H · 2001 to 2011
$38.1M
NCRR NIH HHS P20 RR016475NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

Although the exact cause or causes of Parkinson's disease (PD) are not fully understood, it is believed that environmental factors play a major role. The discovery that a synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-derived N-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsDopaminergic NeuronsElectron Transport Complex IHep G2 CellsHumansMiceParkinson DiseaseReactive Oxygen Species1-Methyl-4-phenylpyridiniumElectron Transport Complex IReactive Oxygen Speciescomplex I inhibitorsdopaminergic toxinsenvironmental toxinsMPP derivativesParkinson’s diseasereactive oxygen species

Identifiers

PMID30929447
PMCPMC7063993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.