ArticleAnalytical chemistry2019
Nanoparticle Analysis in Biomaterials Using Laser Ablation-Single Particle-Inductively Coupled Plasma Mass Spectrometry.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Development of a Flow-through Cell for Ultrasonic Extraction (UE)─Single Particle (SP)─ICP-MS─an Approach for Nano/Microparticle Elemental and Isotopic Analysis.Analytical chemistry · 2026Article
- A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis.Analytical chemistry · 2025Article
- Evaluation of the Accumulation, Distribution, and Excretion of Different Silver Species in Tissues and Feces from Chickens and Pigs Fed with Silver-Based Nanomaterial Supplemented Feeds.ACS agricultural science & technology · 2025Article
- Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation.Nano convergence · 2024Review
- Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles.Analytical and bioanalytical chemistry · 2024Review
- Expanding the boundaries of atomic spectroscopy at the single-cell level: critical review of SP-ICP-MS, LIBS and LA-ICP-MS advances for the elemental analysis of tissues and single cells.Analytical and bioanalytical chemistry · 2023Review
- Quantitative titanium imaging in fish tissues exposed to titanium dioxide nanoparticles by laser ablation-inductively coupled plasma-mass spectrometry.Mikrochimica acta · 2023Article
- Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2023Article
- Fate of Gold Nanoparticles in Laser Desorption/Ionization Mass Spectrometry: Toward the Imaging of Individual Nanoparticles.Journal of the American Society for Mass Spectrometry · 2023Article
- Size Analysis of Silver and Gold Nanoparticles Using Laser Ablation Single Particle ICP Mass Spectrometry: Evaluation of the Laser-Induced Disintegration of Nanoparticles.Mass spectrometry (Tokyo, Japan) · 2023Article
- Facets of ICP-MS and their potential in the medical sciences-Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays.Analytical and bioanalytical chemistry · 2022Review
- Determination of metallic nanoparticles in biological samples by single particle ICP-MS: a systematic review from sample collection to analysis.Environmental science. Nano · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past decade, the development of single particle-inductively coupled plasma mass spectrometry (SP-ICPMS) has revolutionized the field of nanometallomics. Besides differentiation between dissolved and particulate metal signals, SP-ICPMS can quantify the nanoparticle (NP) number concentration and size. Because SP-ICPMS is limited to characterization of NPs in solution, we show how solid sampling by laser ablation (LA) adds spatial-resolution characteristics for localized NP analysis in biomaterials. Using custom-made gelatin standards doped with dissolved gold and commercial or synthesized gold nanoparticles, LA-SP-ICPMS conditions such as laser fluence, beam size, and dwell time were optimized for NP analysis to minimize NP degradation, peak overlap, and interferences from dissolved gold. A data-processing algorithm to retrieve the NP number concentration and size was developed for this purpose. As a proof-of-concept, a sunflower-root-sample cross-section, originating from a sunflower plant exposed to gold NPs, was successfully imaged using the optimized LA-SP-ICPMS conditions for localized NP characterization.
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Registered trials
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