ArticleThe world journal of men's health2021
Proteomic Profiling of Seminal Plasma Proteins in Varicocele Patients.
Article in The world journal of men's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Heat shock proteins in male infertility: recent advances and clinical implications.Frontiers in cell and developmental biology · 2026Review
- Molecular Remodeling of the Sperm Proteome Following Varicocele Sclero-Embolization: Implications for Semen Quality Improvement.Proteomes · 2025Article
- From imaging techniques to laboratory tests: a multimodal stratification for varicocele-associated decreased semen quality.Basic and clinical andrology · 2025Review
- Research advances in inflammation and oxidative stress in varicocele-induced male infertility: a narrative review.Asian journal of andrology · 2025Review
- Protein profile of spermatozoa and seminal plasma based on molecular weight in four phenotypes ofOpen veterinary journal · 2025Article
- Metabolomic profiling of varicocele-induced male infertility: insights from spermatic vein blood analysis.Frontiers in endocrinology · 2025Article
- Effect of Seminal Plasma on the Freezability of Boar Sperm.Animals : an open access journal from MDPI · 2024Article
- Seminal plasma protein profiles and testosterone levels as biomarker semen quality of candidate Madura bulls.Journal of advanced veterinary and animal research · 2023Article
- Molecular Markers: A New Paradigm in the Prediction of Sperm Freezability.International journal of molecular sciences · 2023Review
- Protein Identification of Seminal Plasma in Bali Bull (Animals : an open access journal from MDPI · 2023Article
- Molecular Interactions Associated with Oxidative Stress-Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.Advances in experimental medicine and biology · 2022Review
- Vitamins as primary or adjunctive treatment in infertile men with varicocele: A systematic review.Arab journal of urology · 2021Article
- Seminal Plasma Proteomic Biomarkers of Oxidative Stress.International journal of molecular sciences · 2020Review
- Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility.The world journal of men's health · 2020Review
- Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility.International journal of molecular sciences · 2020Review
- Alterations in seminal plasma proteomic profile in men with primary and secondary infertility.Scientific reports · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeSeminal plasma provides a nutritive and protective milieu for spermatozoa. It contains factors/proteins required for sperm maturation, hyperactivation, capacitation and acrosome reaction. Alteration in the expression levels of seminal plasma proteins affect the fertilization process. The main objective of this study is to compare the seminal plasma proteome of healthy fertile men (control group) with varicocele patients in order to identify the differentially expressed seminal plasma proteins. MATERIALS AND
methodsPooled seminal plasma samples from control (n=5) and varicocele (unilateral: n=5 and bilateral: n=5) subjects were used for proteomic profiling and functional bioinformatic analysis. Key differentially expressed proteins (DEPs) associated with binding of zona pellucida (acrosin; ACR), protein folding (heat shock related 70 kDa protein 2; HSPA2), oxidative stress (peroxiredoxin 2; PRDX2), lipid peroxidation and DNA fragmentation (apolipoprotein A2; APOA2) were validated by Western blot. Statistical analysis was conducted using Mann-Whitney test.
resultsA total of 412 and 486 proteins were detected in seminal plasma of control group and varicocele patients respectively. Twenty-eight proteins were identified as DEPs between varicocele and control group. Validation of DEPs revealed downregulation of HSPA2 (p=0.0037) as well as APOA2 (p=0.0373), and upregulation of PRDX2 (p=0.0474).
conclusionsThe seminal plasma protein profile of varicocele patients differ from healthy fertile men. Aberrant expression of seminal plasma proteins serve as an indicator of sperm pathology in varicocele patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.