ArticleThe European journal of neuroscience2020
Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females.
Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality.GeroScience · 2025Pooled it
- Insufficient sleep and weekend recovery sleep: classification by a metabolomics-based machine learning ensemble.Scientific reports · 2023Trial
- Trial
- Impact of Daily Rhythms and Postprandial Responses on the Plasma Metabolome.International journal of molecular sciences · 2026Article
- Leveraging the Metabolic Fingerprint of Sleep Deprivation and Sleep Restriction for Forensic Applications: A Machine Learning Study in Oral Fluid Metabolomics.Journal of proteome research · 2026Article
- Sleep regularity, circadian rhythms, and chronotype as mechanisms of risk for affective dysregulation in female adolescents.Development and psychopathology · 2026Article
- Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL.medRxiv : the preprint server for health sciences · 2026Article
- Observational
- Article
- Sleep and circadian disruption reshape immune homeostasis in oral tissues: mechanistic roles of melatonin and cortisol in periodontal disease and xerostomia.Frontiers in immunology · 2026Review
- Bidirectional effects of physical activity and sleep on health: evidence and future directions.Frontiers in sports and active living · 2026Review
- Daily rhythm in DNA methylation and the effect of total sleep deprivation.Journal of sleep research · 2025Article
- Circadian Biomarkers in Humans: Methodological Insights into the Detection of Melatonin and Cortisol.Biomolecules · 2025Review
- Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics.Npj biological timing and sleep · 2025Article
- Exposing 24-hour cycles in bile acids of male humans.Nature communications · 2024Article
- Sleep insufficiency, circadian rhythms, and metabolomics: the connection between metabolic and sleep disorders.Sleep & breathing = Schlaf & Atmung · 2023Review
- Daily rhythms of diabetogenic factors in men: role of type 2 diabetes and body weight.Endocrine connections · 2023Article
- Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials.Journal of the American Heart Association · 2023Article
- Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines.Metabolites · 2023Article
- Machine learning estimation of human body time using metabolomic profiling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Disruption to sleep and circadian rhythms can impact on metabolism. The study aimed to investigate the effect of acute sleep deprivation on plasma melatonin, cortisol and metabolites, to increase understanding of the metabolic pathways involved in sleep/wake regulation processes. Twelve healthy young female participants remained in controlled laboratory conditions for ~92 hr with respect to posture, meals and environmental light (18:00-23:00 hr and 07:00-09:00 hr <8 lux; 23:00-07:00 hr 0 lux (sleep opportunity) or <8 lux (continuous wakefulness); 09:00-18:00 hr ~90 lux). Regular blood samples were collected for 70 hr for plasma melatonin and cortisol, and targeted liquid chromatography-mass spectrometry metabolomics. Timepoints between 00:00 and 06:00 hr for day 1 (baseline sleep), day 2 (sleep deprivation) and day 3 (recovery sleep) were analysed. Cosinor analysis and MetaCycle analysis were performed for detection of rhythmicity. Night-time melatonin levels were significantly increased during sleep deprivation and returned to baseline levels during recovery sleep. No significant differences were observed in cortisol levels. Of 130 plasma metabolites quantified, 41 metabolites were significantly altered across the study nights, with the majority decreasing during sleep deprivation, most notably phosphatidylcholines. In cosinor analysis, 58 metabolites maintained their rhythmicity across the study days, with the majority showing a phase advance during acute sleep deprivation. This observation differs to that previously reported for males. Our study is the first of metabolic profiling in females during sleep deprivation and recovery sleep, and offers a novel view of human sleep/wake regulation and sex differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.