Trial reportClinical pharmacology and therapeutics2019
Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain.
Trial report in Clinical pharmacology and therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials.Clinics (Sao Paulo, Brazil)Pooled it
- Cai's gynecology cyclical therapy with stasis-clearing and meridian-warming method for primary dysmenorrhea: a randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Individualizing NSAID therapy in axial spondyloarthritis: N-of-1 trials with Bayesian analysis.Rheumatology (Oxford, England) · 2025Trial
- Clinical effects of different virtual reality presentation content on anxiety and pain: a randomized controlled trial.Scientific reports · 2023Trial
- Oral and Maxillofacial Surgeon Accuracy in Anticipating Supplemental Opioid Use Following Third Molar Extraction.medRxiv : the preprint server for health sciences · 2026Article
- Predictors of Supplemental Opioid Use After Third Molar Extraction.medRxiv : the preprint server for health sciences · 2025Article
- Cannabidiol for Toothache: Ups, Downs, and Regulatory Considerations.Journal of dental research · 2024Article
- Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.Scientific reports · 2023Review
- Acute inflammatory response via neutrophil activation protects against the development of chronic pain.Science translational medicine · 2022Article
- Distribution of Opioid Prescribing and High-Risk Prescribing Among U.S. Dentists in 2019.American journal of preventive medicine · 2022Article
- Chemokines and Pain in the Trigeminal System.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Multifocal Analysis of Acute Pain After Third Molar Removal.Frontiers in pharmacology · 2021Article
- Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain.Journal of dental research · 2020Article
- NSAID-Gut Microbiota Interactions.Frontiers in pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
The mechanisms underlying interindividual variability in analgesic efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) are not well understood. Therefore, we performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expression profiling in healthy subjects who underwent surgical extraction of bony impacted third molars and were treated with ibuprofen (400 mg; N = 19) or placebo (N = 10). Analgesic efficacy was not associated with demographic or clinical characteristics, ibuprofen pharmacokinetics, or the degree of cyclooxygenase inhibition by ibuprofen. Compared with partial responders to ibuprofen (N = 9, required rescue medication within the dosing interval), complete responders (N = 10, no rescue medication) exhibited greater induction of urinary prostaglandin metabolites and serum tumor necrosis factor-α and interleukin 8. Differentially expressed genes in peripheral blood mononuclear cells were enriched for inflammation-related pathways. These findings suggest that a less pronounced activation of the inflammatory prostanoid system is associated with insufficient pain relief on ibuprofen alone and the need for additional therapeutic intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.