Evidence map›Paper›PMID 30929147›Full record

ArticleAIDS and behavior2019

The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).

Cenk Yildirim, Patricia A Garvie, Miriam Chernoff, Megan L Wilkins, E Doyle Patton, Paige L Williams, Sharon L Nichols, Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01418014 completednot on this map

Adolescent Master Protocol

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2021Enrolled678ConditionsHIV/AIDS
NCT02119702 completednot on this map

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2014 to 2025Enrolled818ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cenk YildirimCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, FXB Building 5th floor, 677 Huntington Ave, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-5615-3936
Patricia A GarvieResearch Department, Children's Diagnostic & Treatment Center, Fort Lauderdale, FL, USA.
Miriam ChernoffCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, FXB Building 5th floor, 677 Huntington Ave, Boston, MA, 02115, USA.
Megan L WilkinsSt. Jude Children's Research Hospital, Memphis, TN, USA.
E Doyle PattonPatton Psychology Associates, Inc., Aventura, FL, USA.
Paige L WilliamsCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, FXB Building 5th floor, 677 Huntington Ave, Boston, MA, 02115, USA.
Sharon L NicholsDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, Mail Code 0935, La Jolla, CA, 92093, USA. slnichols@ucsd.edu.
Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
Memory Functioning in Children and Adolescents with Perinatal HIV InfectionR01MH084794 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NICHOLS, SHARON L · 2010 to 2014
$2.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development (US) HD052102 / HD052104National Institute of Mental Health MH084794NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104NIMH NIH HHS R01 MH084794
6 · The paper itself

Abstract

Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09-0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.

Indexed as

Antiretroviral Therapy, Highly ActiveDrug MonitoringPatient Acceptance of Health CareAdolescentAdultAnti-HIV AgentsFemaleHIV-1HIV InfectionsHumansInfectious Disease Transmission, VerticalMaleOutcome and Process Assessment, Health CarePharmaceutical ServicesPharmaciesSelf ReportAnti-HIV AgentsAppointment adherenceARV adherencePediatric HIVPharmacy refillSelf-report

Identifiers

PMID30929147
PMCPMC6650348

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.