Evidence map›Paper›PMID 30929108›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2019

ISCEV extended protocol for the stimulus-response series for light-adapted full-field ERG.

Daphne L McCulloch, Mineo Kondo, Ruth Hamilton, Pierre Lachapelle, André M V Messias, Anthony G Robson, Shinji Ueno

Abstract read
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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. ISCEV and IPS guideline for the full-field stimulus test (FST).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Guideline
  2. VEP estimation of visual acuity: a systematic review.Documenta ophthalmologica. Advances in ophthalmology · 2021
    Pooled it
  3. Review
  4. Article
  5. Article
  6. ISCEV standard for clinical visual evoked potentials (2025 update).Documenta ophthalmologica. Advances in ophthalmology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. ISCEV standard for clinical pattern electroretinography (2024 update).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Flicker electroretinogram in newborn infants.Documenta ophthalmologica. Advances in ophthalmology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daphne L McCullochSchool of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada. daphne.mcculloch@uwaterloo.ca.ORCID 0000-0003-3519-4207
Mineo KondoMie University Graduate School of Medicine, Mie, Japan.
Ruth HamiltonClinical Physics and Bio-engineering, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK.
Pierre LachapelleDepartment of Ophthalmology and Neurology-Neurosurgery, McGill University, Montreal, QC, Canada.
André M V MessiasOftalmologia e Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Anthony G RobsonDepartment of Electrophysiology, Moorfields Eye Hospital, London, UK.
Shinji UenoOphthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum protocol for clinical testing but encourages additional ERG testing when appropriate. This ISCEV extended protocol describes methods to record and evaluate a light-adapted (LA) ERG stimulus-response series with increasing flash strengths. The LA ERG stimulus-response series (also referred to as the luminance-response or intensity-response series in the published literature) can characterise generalised cone system function more comprehensively than the ISCEV standard LA ERGs alone. The amplitude of LA ERG a-waves, arising from cones and cone off-bipolar cells, typically shows a saturating function. The LA ERG b-wave amplitudes, which arise primarily from activity of retinal bipolar cells, show an amplitude peak followed by a nonzero plateau (the "photopic hill" phenomenon). This ISCEV extended protocol specifies a stimulus-response series suitable to evaluate generalised dysfunction affecting the LA retina, to aid in distinguishing between the on- and off-responses of the cone system and to monitor ERG changes in these characteristics. The LA ERG stimulus-response series for a- and b-waves is recorded to a sequence of nine flash stimuli ranging from 0.03 to 300 cd s m

Indexed as

LightAdultClinical ProtocolsElectroretinographyEye Diseases, HereditaryGenetic Diseases, X-LinkedHumansMyopiaNight BlindnessOphthalmologyPhotic StimulationRetinaRetinal Cone Photoreceptor CellsSocieties, MedicalClinical standardsElectroretinogram (ERG)Full-field ERGInternational society for clinical electrophysiology of vision (ISCEV)ISCEV extended protocolLight-adapted (LA)Photopic hillRetinal dystrophyRetinopathyStimulus–response series

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.