ReviewCurrent treatment options in cardiovascular medicine2019
Mitral Annular Calcification and Calcific Mitral Stenosis: Therapeutic Challenges and Considerations.
Review in Current treatment options in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Pearls and pitfalls in the diagnosis and management of mitral annular calcification.Heart (British Cardiac Society) · 2026Article
- Contemporary Review of Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant Mitral Stenosis.Current cardiology reviews · 2026Review
- Impact of left-heart myopathy on mitral valve stenosis assessment and interventional outcomes: anEuropean heart journal. Digital health · 2026Article
- Mitral Annular Calcification and Valve Dysfunction: Insights and Future Directions.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2024Article
- Degenerative Mitral Stenosis: A Case-Based Review.CASE (Philadelphia, Pa.) · 2023Article
- Degenerative Mitral Stenosis-Diagnostic Challenges and Future Directions.Reviews in cardiovascular medicine · 2022Review
- Mitral Valve Dysfunction in Patients With Annular Calcification: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2022Review
- Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction.European heart journal · 2020Article
- Article
- State-of-the-art Structural Interventions in Heart Failure.Cardiac failure review · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewMitral annular calcification (MAC) and associated calcific mitral stenosis (MS) are frequent in the aging population, although optimal management remains debated and outcomes are poor. This article summarizes challenges in the diagnosis and therapy of calcific MS, the indications for valve intervention, procedural concerns, and emerging treatment options. RECENT
findingsSurgical mitral valve replacement is the procedure of choice in symptomatic patients at acceptable surgical risk, with transcatheter mitral valve replacement (TMVR) being evaluated in clinical trials as an alternative for patients at prohibitive surgical risk. Significant challenges exist with the currently available technology and outcomes have been suboptimal. Optimizing the patient-selection process by using multimodality imaging tools has proven to be essential. MAC and calcific MS is an increasingly prevalent, challenging issue with poor outcomes. While surgical valve replacement can be performed in patients with acceptable surgical risk, TMVR can be considered for patients at higher risk. Clinical trials are underway to optimize outcomes. Dedicated device designs and techniques to minimize risk of left ventricular outflow tract obstruction, paravalvular leakage, and device embolization are to be awaited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.