ArticleBrain structure & function2019
Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library.
Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Homeostatic bidirectional plasticity in upbound and downbound micromodules in a model of the olivocerebellar loop.PLoS computational biology · 2025Article
- Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.Human molecular genetics · 2024Article
- Structural and Functional Organization of Visual Responses in the Inferior Olive of Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A universal workflow for creation, validation, and generalization of detailed neuronal models.Patterns (New York, N.Y.) · 2023Article
- Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1.bioRxiv : the preprint server for biology · 2023Article
- Article
- Strategies for Targeting Neural Circuits: How to Manipulate Neurons Using Virus Vehicles.Frontiers in neural circuits · 2022Review
- Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive NetworkFrontiers in cellular neuroscience · 2022Article
- Article
- Dendritic Architecture PredictsFrontiers in neural circuits · 2021Article
- Article
- Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior OliveFrontiers in cellular neuroscience · 2020Article
- Neocortex-Cerebellum Circuits for Cognitive Processing.Trends in neurosciences · 2020Review
- Role of cerebellar GABAergic dysfunctions in the origins of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Quasiperiodic rhythms of the inferior olive.PLoS computational biology · 2019Article
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
The inferior olive (IO) is an evolutionarily conserved brain stem structure and its output activity plays a major role in the cerebellar computation necessary for controlling the temporal accuracy of motor behavior. The precise timing and synchronization of IO network activity has been attributed to the dendro-dendritic gap junctions mediating electrical coupling within the IO nucleus. Thus, the dendritic morphology and spatial arrangement of IO neurons governs how synchronized activity emerges in this nucleus. To date, IO neuron structural properties have been characterized in few studies and with small numbers of neurons; these investigations have described IO neurons as belonging to two morphologically distinct types, "curly" and "straight". In this work we collect a large number of individual IO neuron morphologies visualized using different labeling techniques and present a thorough examination of their morphological properties and spatial arrangement within the olivary neuropil. Our results show that the extensive heterogeneity in IO neuron dendritic morphologies occupies a continuous range between the classically described "curly" and "straight" types, and that this continuum is well represented by a relatively simple measure of "straightness". Furthermore, we find that IO neuron dendritic trees are often directionally oriented. Combined with an examination of cell body density distributions and dendritic orientation of adjacent IO neurons, our results suggest that the IO network may be organized into groups of densely coupled neurons interspersed with areas of weaker coupling.
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