Evidence map›Paper›PMID 30928977›Full record

ArticleObesity facts2019

Secretion of Gut Hormones and Expression of Sweet Taste Receptors and Glucose Transporters in a Rat Model of Obesity.

Ri Lu Feng, Cheng Qian, Lian Yong Liu, Qian Jing Liu, Yun Qiu Jin, Sheng Xian Li, Wei Liu, Chris K Rayner, Jing Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ri Lu FengDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Cheng QianDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Lian Yong LiuDepartment of Endocrinology and Metabolism, Shanghai Punan Hospital, Shanghai, China.
Qian Jing LiuDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Yun Qiu JinDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Sheng Xian LiDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Wei LiuDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
Chris K RaynerDiscipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Jing MaDivision of Endocrinology and Metabolism, School of Medicine, Renji Hospital affiliated to Shanghai Jiaotong University, Shanghai, China, majing3436@163.com.
Renji Hospital · CNPunan Hospital · CNUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study was undertaken to compare gut hormone secretion between high-fat-fed and control rats, and to examine the corresponding changes in the expression of sweet taste receptors and glucose transporters in the small intestine and hypothalamus.

methodsFour-week-old male Sprague Dawley rats were fed a standard or high-fat diet for 8 weeks (10 in each group), followed by an oral glucose tolerance test (50% glucose solution, 2 g/kg). Blood was sampled for glucose, insulin, glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) assays. One week later, small intestinal and hypothalamic tissue were analyzed for sweet taste receptor and glucose transporter expression by real-time PCR.

resultsAfter oral glucose, plasma GLP-1 concentrations were higher in high-fat-fed than standard-fat-fed rats (group × time interaction, p < 0.01) with significant differences at t = 15 min (p < 0.01) and 30 min (p < 0.05). Plasma PYY concentrations were lower in high-fat-fed than control rats at t = 0, 15 min (p < 0.05, respectively) and 120 min (p < 0.01). There were no differences in the expression of sweet taste receptors or glucose transporters between high-fat-fed and control rats in the duodenum, ileum, or hypothalamus.

conclusionsChanges in GLP-1 and PYY secretion after a high-fat diet appear unrelated to any changes in the expression of sweet taste receptors or glucose transporters. Impaired PYY secretion with high-fat feeding suggests that PYY analogues may provide a potential therapy in the treatment of obesity.

Indexed as

ObesityTasteAnimalsDiet, High-FatGastrointestinal HormonesGene ExpressionGlucagon-Like Peptide 1GlucoseGlucose Tolerance TestGlucose Transport Proteins, FacilitativeIleumInsulinMalePeptide YYRatsRats, Sprague-DawleyGastrointestinal HormonesGlucagon-Like Peptide 1GlucoseGlucose Transport Proteins, FacilitativeInsulinPeptide YYReceptors, G-Protein-CoupledGut hormonesObesitySweet taste receptors

Identifiers

PMID30928977
PMCPMC6547286
OpenAlexW2930109045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.