Evidence map›Paper›PMID 30928957›Full record

ArticleBMJ open2019

Dose-response association between physical activity and non-alcoholic fatty liver disease: a case-control study in a Chinese population.

YangFan Li, Fei He, Yun He, XinTing Pan, YunLi Wu, ZhiJian Hu, Xu Lin, ShangHua Xu, Xian-E Peng

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Aerobic Exercise in the Management of Metabolic Dysfunction Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Review
  11. Review
  12. Non-alcoholic fatty liver disease in lean individuals.JHEP reports : innovation in hepatology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

YangFan Li *Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, Fuzhou, China.
Fei He *Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, Fuzhou, China.
Yun HeKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, Fuzhou, China.
XinTing PanDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, Fuzhou, China.
YunLi WuKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, Fuzhou, China.
ZhiJian HuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, Fuzhou, China.
Xu LinKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, Fuzhou, China.
ShangHua XuDepartment of Cardiology, Affiliated Nanping First Hospital, Fujian Medical University, Nanping, China.
Xian-E PengDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPhysical activity plays an important role in the development of non-alcoholic fatty liver disease (NAFLD).However, the optimal intensity and dose of physical activity for the treatment of NAFLD have yet to be found. In the present study, we aimed to provide a dose-response association between physical activity and NAFLD in a Chinese population.

methodsWe recruited 543 patients with NAFLD diagnosed by abdominal ultrasonography, and 543 age-matched and sex-matched controls. The amount of physical activity, sedentary time and energy intake was collected through a structured questionnaire. Logistic regression analyses were performed to investigate the association between physical activity and NAFLD.

resultsAfter adjusting for hypertension, diabetes, body mass index, fasting blood glucose, energy intake and sedentary time, the total amount of physical activity was found to be inversely associated with NAFLD in a dose-dependent manner in men (>3180 metabolic equivalent of energy [MET]-min/week vs ≤1440 MET-min/week: OR 0.60, 95% CI 0.40 to 0.91, p for trend=0.01). In addition, both moderate-intensity and vigorous-intensity physical activity were effective in reducing the risk of NAFLD, independent of confounding variables in men (moderate-intensity physical activity: >684 MET-min/week vs none: OR 0.58, 95% CI 0.40 to 0.86, p for trend=0.01; vigorous-intensity physical activity: >960 MET-min/week vs none: OR 0.63, 95% CI 0.41 to 0.95, p for trend=0.02).

conclusionsPhysical activity was inversely associated with risk of NAFLD in a dose-dependent manner in men. Vigorous-intensity and moderate-intensity physical activity were both beneficial to NAFLD, independent of sedentary time and energy intake.

Indexed as

AdultAgedCase-Control StudiesChinaEnergy IntakeExerciseFemaleHumansLogistic ModelsMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseRisk FactorsSedentary BehaviorYoung Adulthepatologylipid disorderspublic healthsports medicine

Identifiers

PMID30928957
PMCPMC6475196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.