ArticleBMJ open2019
Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997-2011.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Medication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies.Orphanet journal of rare diseases · 2024Pooled it
- Article
- Trends in Gastroschisis in the State of Paraná, Brazil: A Study of Incidence, Mortality, and Associated Factors (2013-2024).International journal of environmental research and public health · 2026Article
- How STI trends track changes in sexual behaviour, online dating and sexual orientation demographics: an analysis of reported bacterial STI incidence and three social behavioural surveys in the USA (2010-2024).BMJ public health · 2026Article
- The Impact of Chlamydia Treatment During Pregnancy on Birth Defects in New York State.Birth defects research · 2026Article
- Short interbirth interval and adverse pregnancy outcomes: a Bayesian network approach.AJOG global reports · 2024Article
- Human Milk-Derived Fortifier to Reduce Hospital-Acquired Malnutrition in Uncomplicated Gastroschisis: A Case Report.AJP reports · 2024Article
- County-Level Atrazine Use and Gastroschisis.JAMA network open · 2024Article
- Maternal exposure to zolpidem and risk of specific birth defects.Journal of sleep research · 2024Article
- Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?Birth defects research · 2023Article
- Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries.Birth defects research · 2022Article
- Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011.Paediatric and perinatal epidemiology · 2022Article
- Article
- Characteristics of Women with Urinary Tract Infection in Pregnancy.Journal of women's health (2002) · 2021Article
- Gastroschisis: A State-of-the-Art Review.Children (Basel, Switzerland) · 2020Review
- Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level.Journal of community genetics · 2020Article
- Maternal occupational exposure to solvents and gastroschisis in offspring - National Birth Defects Prevention Study 1997-2011.Occupational and environmental medicine · 2020Article
- New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology.Colombia medica (Cali, Colombia)Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo assess the association between occurrence and timing of maternal self-reported genitourinary tract infection (urinary tract infections [UTIs] and/or sexually transmitted infection [STI]) and risk for gastroschisis in the offspring.
designPopulation-based case-control study.
settingNational Birth Defects Prevention Study, a multisite study in the USA.
participantsMothers of 1366 gastroschisis cases and 11 238 healthy controls.
main outcome measuresCrude and adjusted ORs (aORs) with 95% CIs.
resultsGenitourinary infections were frequent in case (19.3%) and control women (9.9%) during the periconceptional period (defined as 3 months prior to 3 months after conception). UTI and/or STI in the periconceptional period were associated with similarly increased risks for gastroschisis (aOR 1.5, 95% CI 1.3 to 1.8; aOR 1.6, 95% CI 1.2 to 2.3, respectively). The risk was increased with a UTI before (aOR 2.5; 95% CI 1.4 to 4.5) or after (aOR 1.7; 95% CI 1.1 to 2.6) conception only among women ≥25 years of age. The risk was highest among women <20 years of age with an STI before conception (aOR 3.6; 95% CI 1.5 to 8.4) and in women ≥25 years of age, the risk was similar for before (aOR 2.9; 95% CI 1.0 to 8.5) and after (aOR 2.8; 95% CI 1.3 to 6.1) conception. A specific STI pathogen was reported in 89.3% (50/56) of cases and 84.3% (162/191) of controls with
conclusionsUTI and/or STI were associated with an increased risk for gastroschisis, with the strength of the association varying by maternal age and timing of infection.
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Registered trials
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