Evidence map›Paper›PMID 30928724›Full record

ArticlePsychiatry research2019

Autonomic arousal profiles in adolescents and young adults with ADHD as a function of recording context.

Ebba Du Rietz, Sarah-Naomi James, Tobias Banaschewski, Daniel Brandeis, Philip Asherson, Jonna Kuntsi

Abstract read
In one paragraph

Article in Psychiatry research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Lateralization of attention in adults with ADHD: Evidence of pseudoneglect.European psychiatry : the journal of the Association of European Psychiatrists · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ebba Du RietzKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom. Electronic address: ebba.du_rietz@kcl.ac.uk.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing at UCL, University College London, 33 Bedford Place, London, WC1B 5JU, United Kingdom. Electronic address: sarah.n.james@ucl.ac.uk.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Square J5, 68159 Mannheim, Germany. Electronic address: tobias.banaschewski@zi-mannheim.de.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland. Electronic address: daniel.brandeis@kjpd.uzh.ch.
Philip AshersonKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom. Electronic address: philip.asherson@kcl.ac.uk.
Jonna KuntsiKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom. Electronic address: jonna.kunti@kcl.ac.uk.

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Department of Health NF-SI-0616-10040Medical Research Council 1523460Medical Research Council G0300189NIMH NIH HHS R01 MH062873
6 · The paper itself

Abstract

A recent study (James et al. 2016) found that attention-deficit/hyperactivity disorder (ADHD) was associated with hypo-arousal, indexed by low electrodermal activity, during a low-demand reaction-time task, which normalized in a fast-incentive condition. We now investigate if (1) autonomic arousal in individuals with ADHD changes over a long testing session and (2) across time, to clarify if arousal profiles are context-dependent. We also examine (3) how autonomic arousal relates to each ADHD symptom domain, and specificity of arousal profiles to ADHD, by controlling for oppositional defiant/conduct disorder (ODD/CD) symptoms. Skin conductance level and non-specific fluctuations were measured during four successive resting-state and cognitive conditions (Resting-state time 1, Continuous Performance Task, Fast Task: Baseline and Fast-Incentive conditions, Resting-state time 2) from 71 adolescents/young adults with ADHD and 140 controls. Lower arousal was observed in individuals with ADHD only during a slow, low-demanding task, and more fluctuating arousal was observed towards the end of assessment. Both inattentive and hyperactive-impulsive symptoms were associated with arousal levels and fluctuations, independently from ODD/CD. Overall, we extend previous findings showing that under-arousal, but also fluctuating arousal, are context-specific rather than stable impairments in ADHD.

Indexed as

ArousalAdolescentAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityAutonomic Nervous SystemChildFemaleHumansMaleNeuropsychological TestsReaction TimeYoung AdultADHDElectrodermal activityPhasic arousalSkin conductanceTonic arousal

Identifiers

PMID30928724
PMCPMC6525183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.