ArticleRespiratory physiology & neurobiology2019
Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.
Article in Respiratory physiology & neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Chemoreflex sensitization occurs in both male and female rats during recovery from acute lung injury.Frontiers in physiology · 2024Article
- Cannabinoid Receptor mRNA Expression in Central and Peripheral Tissues in a Rodent Model of Peritonitis.Cannabis and cannabinoid research · 2023Article
- Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.Frontiers in network physiology · 2023Article
- The superior cervical ganglion is involved in chronic chemoreflex sensitization during recovery from acute lung injury.Frontiers in physiology · 2023Article
- Time-dependent alteration in the chemoreflex post-acute lung injury.Frontiers in physiology · 2022Article
- From one breath to the next: an inflammatory rift in the pattern of predictability.The Journal of physiology · 2020Article
- Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.Brain, behavior, and immunity · 2020Article
- All roads lead to inflammation: Is maternal immune activation a common culprit behind environmental factors impacting offspring neural control of breathing?Respiratory physiology & neurobiology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We hypothesize that ventilatory pattern variability (VPV) varies with the magnitude of acute lung injury (ALI). In adult male rats, we instilled a low- or high- dose of bleomycin or saline (PBS) intratracheally. While representative samples of pulmonary tissue indicated graded lung injury, coefficient of variation (CV) of TTOT did not differ among the 3 groups. Broncho-alveolar lavage fluid (BALF), respiratory rate (fR), mutual information were greater in ALI than sham rats; but did not differ between bleomycin doses. However, nonlinear complexity index (NLCI), which is the difference in sample entropy between original and surrogate data sets was greater for high- versus low- dose; but did not differ between low-dose and sham groups. Further, NLCI correlated to an injury index based on protein concentration of BALF and failure to gain weight. Finally, Receiver Operator Curves (ROCs) indicated that both mutual information and NLCI had greater sensitivity and specificity than fR and CVTTOT in identifying ALI. Thus, nonlinear analyses of VPV can distinguish ALI and out performs fR as a biometric.
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Registered trials
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