Evidence map›Paper›PMID 30928400›Full record

ArticleChemico-biological interactions2019

Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid.

Mo Chen, Phumvadee Wangtrakuldee, Tianzhu Zang, Ling Duan, Laura L Gathercole, Jeremy W Tomlinson, Trevor M Penning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mo ChenDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Phumvadee WangtrakuldeeDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tianzhu ZangDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ling DuanDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Laura L GathercoleDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK; Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, Oxford University, UK.
Jeremy W TomlinsonOxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, Oxford University, UK.
Trevor M PenningDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: penning@upenn.edu.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Kinetic and structural analysis of human steroid 5beta-reductase (AKR1D1)F32DK089827 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHEN, MO · 2011 to 2012
$104k
NIDDK NIH HHS F32 DK089827NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Mammalian steroid 5β-reductases belong to the Aldo-Keto Reductase 1D sub-family and are essential for the formation of A-ring 5β-reduced steroids. Steroid 5β-reduction is required for the biosynthesis of bile-acids and the metabolism of all steroid hormones that contain a Δ

Indexed as

AndrostanesAnimalsBiocatalysisCatalytic DomainChromatography, High Pressure LiquidGlutamic AcidHumansIsomerismKineticsLiverMiceOxidation-ReductionOxidoreductasesProtein IsoformsSteroidsSubstrate Specificity3-oxo-5 beta-steroid delta 4-dehydrogenaseandrostaneAndrostanesGlutamic AcidOxidoreductasesProtein IsoformsSteroidsAldo-keto reductaseHydroxysteroid dehydrogenaseSteroid 5β-reductase

Identifiers

PMID30928400
PMCPMC6500757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.