Evidence map›Paper›PMID 30928339›Full record

ArticleNeuroscience2019

TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy.

Piera Smeriglio, Felix V Wangsawihardja, Rose Leu, Mirna Mustapha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Piera SmeriglioDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Felix V WangsawihardjaDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Rose LeuDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Mirna MustaphaDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, CA, USA. Electronic address: mirnam@stanford.edu.
Stanford University · US

Funding

Understanding thyroid hormone regulation of neurogenesis in the cochleaR01DC009590 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUSTAPHA, MIRNA · 2009 to 2013
$1.8M
NIDCD NIH HHS R01 DC009590
6 · The paper itself

Abstract

Thrombospondins (TSPs) are cell adhesion molecules that play an important role in the maintenance of hearing and afferent synaptic connections. Based on their reported function in restoring synaptic connections after stroke, we tested a potential role for TSP1 and TSP2 genes in repairing cochlear synapses following noise injury. We observed a tonotopic gradient in the expression of TSP1 and TSP2 mRNA in control mouse cochleae and an upregulation of these genes following noise exposure. Examining the functional sequelae of these changes revealed that afferent synaptic counts and auditory brainstem responses (ABRs) in noise-exposed TSP1 and TSP2 knockout (-/-) mice exhibited a worst recovery when compared to controls. Consistent with their tonotopic expression, TSP1-/- mice showed greater susceptibility to noise-induced hearing loss (NIHL) at 8 kHz and 16 kHz frequencies, whereas NIHL in TSP2-/- mice occurred only at mid and high frequencies. Further analysis of the ABR waveforms indicated peripheral neuronal damage in TSP2-/- but not in TSP1-/- mice. Noise trauma affecting mid to high frequencies triggered severe seizures in the TSP2-/- mice. We found that decreased susceptibility to audiogenic seizures in TSP1-/- mice was correlated with increased TSP2 protein levels in their inner ears, suggesting that TSP2 might functionally compensate for the loss of TSP1 in these mice. Our data indicate that TSP1 and TSP2 are both involved in susceptibility to NIHL, with TSP2 playing a more prominent role.

Indexed as

AnimalsAuditory ThresholdCalcium ChannelsCochleaEvoked Potentials, Auditory, Brain StemGene Expression RegulationHearing Loss, Noise-InducedMiceMice, KnockoutNeuronsSpiral GanglionThrombospondin 1Thrombospondin 2ThrombospondinsCACNA2D1 protein, mouseCalcium ChannelsThrombospondin 1Thrombospondin 2Thrombospondinsaudiogenic seizureauditory synaptopathyauditory systemnoise- damaged

Identifiers

PMID30928339
PMCPMC6556133
OpenAlexW2934064945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.