Evidence map›Paper›PMID 30928217›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2019

Ventricular interactions and electromechanical dyssynchrony after Ross and Ross-Konno operations.

Michal Schäfer, Lorna P Browne, Johannes C von Alvensleben, Max B Mitchell, Gareth J Morgan, D Dunbar Ivy, James Jaggers

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Article in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Ross-Konno procedure for congenital aortic stenosis.Annals of cardiothoracic surgery · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Michal SchäferDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo. Electronic address: michal.schafer@ucdenver.edu.
Lorna P BrowneDepartment of Radiology, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.
Johannes C von AlvenslebenDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.
Max B MitchellSection of Congenital Heart Surgery, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.
Gareth J MorganDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.
D Dunbar IvyDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.
James JaggersSection of Congenital Heart Surgery, Heart Institute, Children's Hospital Colorado, University of Colorado Denver Anschutz Medical Campus, Aurora, Colo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRoss and Ross-Konno operations are associated with the inherent risk of residual ventricular septal dysfunction and injury to the conduction system. However, comprehensive biventricular functional outcomes on magnetic resonance imaging after Ross and Ross-Konno procedures are unknown. The purpose of this study was to evaluate and compare the degree of electrical and mechanical dyssynchrony using cardiac magnetic resonance imaging in patients late after Ross and Ross-Konno operations.

methodsPatients following Ross operation (n = 16), Ross-Konno operation (n = 13), and healthy controls (n = 12) underwent cardiac magnetic resonance imaging strain deformation analysis to quantify left ventricular (LV) intraventricular dyssynchrony and right ventricular (RV)-LV interventricular dyssynchrony. Mechanical dyssynchrony indices were correlated with the degree of electrical dyssynchrony as assessed by QRS duration, as well as with magnetic resonance imaging-derived biventricular and autograft regurgitation parameters.

resultsPatients in the Ross and Ross-Konno groups had reduced LV global longitudinal strain when compared with controls (both P values < .01). Both Ross (P < .05) and Ross-Konno (P < .01) groups demonstrated increased RV-LV interventricular dyssynchrony compared with controls. Patients in the Ross-Konno group also had increased septal LV intraventricular dyssynchrony when compared with control and Ross groups (both P values < .01). The global LV intramechanical dyssynchrony strongly correlated with QRS duration (R = 0.716; P < .001). There was no association between mechanical dyssynchrony and aortic regurgitation fraction.

conclusionsLong-term follow-up of patients who underwent Ross and Ross-Konno operations demonstrates reduced LV global longitudinal strain suggestive of chronically increased afterload independent of autograft function. Additionally, Ross-Konno operation is associated with impaired LV intraventricular mechanics and electrical dyssynchrony.

Indexed as

AdolescentAdultAortic Valve StenosisAutograftsCase-Control StudiesChildFemaleHeart VentriclesHemodynamicsHumansMagnetic Resonance ImagingMalePulmonary ValveRetrospective StudiesVentricular Dysfunction, LeftVentricular Dysfunction, Rightelectromechanical dyssynchronyRoss-Konno operationRoss operation

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.