Evidence map›Paper›PMID 30927986›Full record

ArticleArchives of psychiatric nursing2019

Exploring the mutual regulation between oxytocin and cortisol as a marker of resilience.

Yang Li, Afton L Hassett, Julia S Seng

Abstract read
In one paragraph

Article in Archives of psychiatric nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  5. Stress and parental behaviors.Neuroscience research · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Biomarkers of stress resilience: A review.Neuroscience applied · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Association between Dissociative Symptoms and Morning Cortisol Levels in Patients with Post-traumatic Stress Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Article
  19. Review
  20. Resilience to Combat the COVID-19 pandemic and beyond.Archives of psychiatric nursing · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yang LiUniversity of Missouri Sinclair School of Nursing, Columbia, MO, 65211, USA. Electronic address: liy5@missouri.edu.
Afton L HassettDepartment of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Ann Arbor, MI, 48106, USA.
Julia S SengUniversity of Michigan School of Nursing, 400 North Ingalls Street, Ann Arbor, MI, 48109, USA.
University of Michigan–Ann Arbor · USUniversity of Missouri · US

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTROM, REBECCA L · 1985 to 2007
$40.8M
MESA Center for Health DisparitiesP20NR008367 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THERRIEN, BARBARA A · 2002 to 2006
$1.2M
NCRR NIH HHS M01 RR000042NINR NIH HHS P20 NR008367
6 · The paper itself

Abstract

Early trauma can increase the risk for developing posttraumatic stress disorder (PTSD) in adulthood. Early trauma has also been associated with the dysregulation between the hypothalamic-pituitary-adrenal (HPA) and oxytocin systems and may influence the co-regulation between these two systems. But whether the mutual regulation of the two systems represents a sign of resilience and/or mutual dysregulation could be a sign of vulnerability to PTSD and the dissociative subtype of PTSD (PTSD-D) is unknown. The study aims to synthesize and conduct a preliminary test of a conceptual model of the mutual regulation between these two systems as a marker of resilience. We analyzed a pilot data with 22 pregnant women in 3 groups (PTSD only, PTSD-D, and trauma-exposed resilient controls) and repeated measures of plasma oxytocin and cortisol. Oxytocin and cortisol seemed reciprocal in all three groups, but both levels were relatively high in women with PTSD-D and low in those with PTSD compared with controls. This suggests that both hormones in women with PTSD-D and PTSD only are dysregulated, but not lacking in reciprocity.

Indexed as

Resilience, PsychologicalAdultBiomarkersFemaleHumansHydrocortisoneHyperemesis GravidarumOxytocinPregnancyStress Disorders, Post-TraumaticTime FactorsBiomarkersHydrocortisoneOxytocinCortisolDissociationOxytocinPosttraumatic stress disorderResilience

Identifiers

PMID30927986
PMCPMC6442937
OpenAlexW2901058552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.