ArticleBMC neurology2019
A case of methylprednisolone treatment for metronidazole-induced encephalopathy.
Article in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Metronidazole-induced cerebellar dysfunction: An underdiagnosed identity.Journal of family medicine and primary care · 2025Article
- Metronidazole-induced encephalopathy in a patient with cirrhosis.Radiology case reports · 2024Article
- Metronidazole-Induced Encephalopathy in a 16-Year-Old Girl with Crohn's Disease: Case Report and Review of the Pediatric Literature.Children (Basel, Switzerland) · 2022Article
- Exacerbation of Mania due to Metronidazole in a Bipolar Disorder Patient.Case reports in psychiatry · 2022Article
- Metronidazole, an Uncommon Cause of Dizziness and Ataxia in the Emergency Department: A Case Report.Clinical practice and cases in emergency medicine · 2021Article
- Metronidazole-induced reversible cerebellar dysfunction.BMJ case reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMetronidazole, a common antimicrobial agent, can induce encephalopathy in rare cases. After discontinuing metronidazole, most patients show clinical improvement. However, in the face of deteriorating conditions, there have done not to have reports of effective drug treatment. CASE PRESENTATION: A 57-year-old man was admitted to our hospital due to dysarthria and ataxic gait after taking metronidazole at the dose of about 32 g for 20 days. Neurological examination showed that his upward and outward movements of bilateral eyeballs were limited, and horizontal and vertical nystagmus were noted. The brain magnetic resonance imaging showed hyper-intensities in the bilateral cerebellar dentate nuclei, medulla oblongata, midbrain and red nuclei in T2W and FLAIR images. However, the patient's clinical symptoms worsened after drug cessation. High-dose intravenous methylprednisolone pulse therapy was applied, and this led to a drastic improvement of his symptoms and signs.
conclusionsIn our case, we suggest that early methylprednisolone intervention can prevent the progression of metronidazole-induced encephalopathy and accelerate neurological recovery. We infer that the progression of encephalopathy is related to the delayed toxicity caused by high dose or concentration of metronidazole.
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