ArticleNeuroImage. Clinical2019
Spectral entropy indicates electrophysiological and hemodynamic changes in drug-resistant epilepsy - A multimodal MREG study.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Brain Pulsation Imaging Using Non-Balanced Steady-State Free Precession With 3D-EPI Readout.Magnetic resonance in medicine · 2026Article
- Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia.Frontiers in cellular neuroscience · 2026Article
- Electrophysiological biomarkers for foundational signal markers in chronic pancreatitis using machine learning models.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- A mega-analysis of low frequency resting-state measures in mood and psychosis-spectrum disorders.medRxiv : the preprint server for health sciences · 2025Article
- Repetitive active and passive cognitive stimulations induce EEG changes in patients with Rett syndrome.Pediatric research · 2025Article
- Improving Transmission Line Fault Diagnosis Based on EEMD and Power Spectral Entropy.Entropy (Basel, Switzerland) · 2024Article
- Alterations of apparent diffusion coefficient from ultra high b-values in the bilateral thalamus and striatum in MRI-negative drug-resistant epilepsy.Epilepsia open · 2024Article
- A Mechanistic Model of Perceptual Binding Predicts That Binding Mechanism Is Robust against Noise.Entropy (Basel, Switzerland) · 2024Article
- Information-Theoretic Approaches in EEG Correlates of Auditory Perceptual Awareness under Informational Masking.Biology · 2023Article
- Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model.Molecular neurobiology · 2023Article
- Functional Near-Infrared Spectroscopy as a Personalized Digital Healthcare Tool for Brain Monitoring.Journal of clinical neurology (Seoul, Korea) · 2023Review
- Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations.Frontiers in neuroscience · 2023Article
- Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea.International journal of molecular sciences · 2022Article
- Fast Sleep Stage Classification Using Cascaded Support Vector Machines with Single-Channel EEG Signals.Sensors (Basel, Switzerland) · 2022Article
- Rail Corrugation Detection and Characterization Using Computer Vision.Sensors (Basel, Switzerland) · 2021Article
- Spectral analysis of physiological brain pulsations affecting the BOLD signal.Human brain mapping · 2021Article
- Implications of Noise on Neural Correlates of Consciousness: A Computational Analysis of Stochastic Systems of Mutually Connected Processes.Entropy (Basel, Switzerland) · 2021Article
- 15 Years MR-encephalography.Magma (New York, N.Y.) · 2021Review
- In Vivo Imaging of Neuroinflammatory Targets in Treatment-Resistant Epilepsy.Current neurology and neuroscience reports · 2020Review
- Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study.Brain communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpilepsy causes measurable irregularity over a range of brain signal frequencies, as well as autonomic nervous system functions that modulate heart and respiratory rate variability. Imaging dynamic neuronal signals utilizing simultaneously acquired ultra-fast 10 Hz magnetic resonance encephalography (MREG), direct current electroencephalography (DC-EEG), and near-infrared spectroscopy (NIRS) can provide a more comprehensive picture of human brain function. Spectral entropy (SE) is a nonlinear method to summarize signal power irregularity over measured frequencies. SE was used as a joint measure to study whether spectral signal irregularity over a range of brain signal frequencies based on synchronous multimodal brain signals could provide new insights in the neural underpinnings of epileptiform activity.
methodsTen patients with focal drug-resistant epilepsy (DRE) and ten healthy controls (HC) were scanned with 10 Hz MREG sequence in combination with EEG, NIRS (measuring oxygenated, deoxygenated, and total hemoglobin: HbO, Hb, and HbT, respectively), and cardiorespiratory signals. After pre-processing, voxelwise SE
resultsRight thalamus, cingulate gyrus, inferior frontal gyrus, and frontal pole showed significantly higher SE
conclusionThis is the first study to show altered spectral entropy from synchronous MREG, EEG, and NIRS in DRE patients. Higher SE
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.