Evidence map›Paper›PMID 30927601›Full record

ArticleNeuroImage. Clinical2019

Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- and

Julie Ottoy, Ellis Niemantsverdriet, Jeroen Verhaeghe, Ellen De Roeck, Hanne Struyfs, Charisse Somers, Leonie Wyffels, Sarah Ceyssens, Sara Van Mossevelde, Tobi Van den Bossche and 6 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  13. Review
  14. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  15. Predictors of Bi-directional Transitions From Mild Cognitive Impairment in a Diverse Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  16. Article
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Julie OttoyMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Ellis NiemantsverdrietReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Jeroen VerhaegheMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Ellen De RoeckReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Hanne StruyfsReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Charisse SomersReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Leonie WyffelsDepartment of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.
Sarah CeyssensDepartment of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.
Sara Van MosseveldeNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Tobi Van den BosscheNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.
Christine Van BroeckhovenNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Annemie RibbensIcometrix, R&D, Leuven, Belgium.
Maria BjerkeReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Sigrid StroobantsDepartment of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.
Sebastiaan EngelborghsReference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Steven StaelensMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium. Electronic address: steven.staelens@uantwerpen.be.
University of Antwerp · BEAntwerp University Hospital · BEVIB-UAntwerp Center for Molecular Neurology · BEIcometrix (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disease-modifying treatment trials are increasingly advanced to the prodromal or preclinical phase of Alzheimer's disease (AD), and inclusion criteria are based on biomarkers rather than clinical symptoms. Therefore, it is of great interest to determine which biomarkers should be combined to accurately predict conversion from mild cognitive impairment (MCI) to AD dementia. However, up to date, only few studies performed a complete A/T/N subject characterization using each of the CSF and imaging markers, or they only investigated long-term (≥ 2 years) prognosis. This study aimed to investigate the association between cerebrospinal fluid (CSF), magnetic resonance imaging (MRI), amyloid- and

Indexed as

Alzheimer DiseaseBiomarkersCognitive DysfunctionDisease ProgressionAgedAmyloid beta-PeptidesAniline CompoundsEthylene GlycolsFemaleFluorodeoxyglucose F18Follow-Up StudiesHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedAmyloid beta-PeptidesAniline CompoundsBiomarkersEthylene GlycolsflorbetapirFluorodeoxyglucose F18Alzheimer's diseaseBiomarkersCerebrospinal fluidFlorbetapirHippocampal volumeMild cognitive impairmentPositron emission tomography

Identifiers

PMID30927601
PMCPMC6444289
OpenAlexW2922380399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.