ArticleNeuroImage. Clinical2019
Relevance of brain lesion location for cognition in vascular mild cognitive impairment.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Fractal dimension of the cortical gray matter outweighs other brain MRI features as a predictor of transition to dementia in patients with mild cognitive impairment and leukoaraiosis.Frontiers in human neuroscience · 2023Article
- Lung function impairment in relation to cognition and vascular brain lesions: the Rotterdam Study.Journal of neurology · 2022Article
- The Effect of Guilingji Capsules on Vascular Mild Cognitive Impairment: A Randomized, Double-Blind, Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Late-life depression accentuates cognitive weaknesses in older adults with small vessel disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition.Alzheimer's research & therapy · 2020Article
- Mechanisms of cognitive dysfunction in CKD.Nature reviews. Nephrology · 2020Review
- Mapping the Progressive Treatment-Related Reduction of Active MRI Lesions in Multiple Sclerosis.Frontiers in neurology · 2020Article
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16 authors.
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Abstract
backgroundVascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) of moderate or severe extension on brain MRI is the hallmark of the VMCI.
objectiveTo assess the clinical relevance of the frequency of WML in patients with VMCI independently of total lesion volume (LV).
methodsIn this multicenter study, we included 110 patients with VMCI (age: 74.3 ± 6.6 years; sex: 60 women). Cognitive assessment was performed with the VMCI-Tuscany Neuropsychological Battery, which allowed to identify four VMCI groups: amnestic single (n = 9) and multi-domain (n = 76), non-amnestic single- (n = 10) and multi-domain (n = 15). Distribution and frequency of WML on MRI FLAIR images were evaluated with lesion probability map (LPM). Voxelwise statistics was performed with nonparametric permutation tests, controlling for age, sex, slice thickness, center, magnetic field strength, total LV and head size (p < .01, family-wise error-corrected for multiple comparisons across space).
resultsLPM of the WML had a fairly symmetric and widespread distribution across brain. A higher frequency of WML along association tracts of the WM such as inferior longitudinal fascicle, inferior fronto-occipital fascicle and superior longitudinal fascicle, was correlated with worst cognitive scores at the Trail Making Test Part A and Copy of the Rey-Osterrieth Complex Figure. The non-amnestic groups showed a higher frequency of WML in the anterior cingulum and superior longitudinal fascicle close to the frontal gyrus.
conclusionsOur study showed that in patients with VMCI, independently of total LV, the higher frequency of lesions along association tracts of the WM, which mediate intrahemispheric long-range connectivity, is related with psychomotor speed and constructional praxis. Moreover, a prevalence of lesions in the frontal WM seems to characterize VMCI patients with involvement of non-amnestic domains.
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