ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Use of the National Institutes of Health Toolbox Cognition Battery in Clinical Populations.Neuropsychology review · 2026Pooled it
- Insular morphological abnormalities in focal to bilateral tonic-clonic seizures.Neuroradiology · 2026Article
- Neuropsychological correlations with fornix and hippocampus in temporal lobe epilepsy demonstrated with diffusion tensor imaging.Epilepsia open · 2026Article
- EEG microstates, spectral analysis, and risk prediction in epilepsy comorbid with mild cognitive impairment: alteration in intrinsic brain activity.Journal of translational medicine · 2025Article
- A specific model of resting-state functional brain network in MRI-negative temporal lobe epilepsy.Heliyon · 2025Article
- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- Article
- Characterizing white matter connectome abnormalities in patients with temporal lobe epilepsy using threshold-free network-based statistics.Brain and behavior · 2024Article
- Adapting to Changes in Communication: The Orbitofrontal Cortex in Language and Speech Processing.Brain sciences · 2024Review
- Epilepsy is associated with the accelerated aging of brain activity in sleep.Frontiers in physiology · 2024Article
- The relevance of Spearman'sBrain communications · 2024Article
- Topological regularization of networks in temporal lobe epilepsy: a structural MRI study.Frontiers in neuroscience · 2024Article
- Machine learning techniques based onFrontiers in neurology · 2024Article
- Morphological and metabolic asymmetries of the thalamic subregions in temporal lobe epilepsy predict cognitive functions.Scientific reports · 2023Article
- Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy.Epilepsia · 2023Article
- Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- The presence, nature and network characteristics of behavioural phenotypes in temporal lobe epilepsy.Brain communications · 2023Article
- Classification of temporal lobe epilepsy based on neuropsychological tests and exploration of its underlying neurobiology.Frontiers in human neuroscience · 2023Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive slowing is a known but comparatively under-investigated neuropsychological complication of the epilepsies in relation to other known cognitive comorbidities such as memory, executive function and language. Here we focus on a novel metric of processing speed, characterize its relative salience compared to other cognitive difficulties in epilepsy, and explore its underlying neurobiological correlates. Research participants included 55 patients with temporal lobe epilepsy (TLE) and 58 healthy controls from the Epilepsy Connectome Project (ECP) who were administered a battery of tests yielding 14 neuropsychological measures, including selected tests from the NIH Toolbox-Cognitive Battery, and underwent 3T MRI and resting state fMRI. TLE patients exhibited a pattern of generalized cognitive impairment with very few lateralized abnormalities. Using the neuropsychological measures, machine learning (Support Vector Machine binary classification model) classified the TLE and control groups with 74% accuracy with processing speed (NIH Toolbox Pattern Comparison Processing Speed Test) the best predictor. In TLE, slower processing speed was associated predominantly with decreased local gyrification in regions including the rostral and caudal middle frontal gyrus, inferior precentral cortex, insula, inferior parietal cortex (angular and supramarginal gyri), lateral occipital cortex, rostral anterior cingulate, and medial orbital frontal regions, as well as three small regions of the temporal lobe. Slower processing speed was also associated with decreased connectivity between the primary visual cortices in both hemispheres and the left supplementary motor area, as well as between the right parieto-occipital sulcus and right middle insular area. Overall, slowed processing speed is an important cognitive comorbidity of TLE associated with altered brain structure and connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.