Evidence map›Paper›PMID 30927381›Full record

Observational studyAddiction (Abingdon, England)2019

Delay discounting and reward sensitivity in a 2 × 2 study of bipolar disorder and alcohol dependence.

William Mellick, Bryan K Tolliver, Helena Brenner, James J Prisciandaro

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

William MellickDepartment of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-5319-0544
Bryan K TolliverDepartment of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA.
Helena BrennerDepartment of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA.
James J PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-8877-7871
Medical University of South Carolina · US

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWARD C. BECKER · 1996 to 2026
$46.8M
Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7M
Neuroimaging mechanisms of overlap between alcoholism and bipolar disorderK23AA020842 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2012 to 2016
$835k
Testing the Effect of GABAergic/glutamatergic Drugs on Relative Brain Activation to Natural Rewards versus Alcohol Cues in Bipolar AlcoholicsF32AA027136 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MELLICK, WILLIAM · 2018 to 2019
$119k
NIAAA NIH HHS F32 AA027136NIAAA NIH HHS K23 AA020842NIAAA NIH HHS P50 AA010761NIAAA NIH HHS R01 AA025365
6 · The paper itself

Abstract

BACKGROUND AND

aimsSeparate studies have shown increased delay discounting in people with bipolar disorder (BD) and people with alcohol dependence (AD) relative to people without mental health problems. Delay discounting was compared in people with no mental health problems, AD, BD and AD plus BD. Associations of delay discounting with self-reported impulsivity and reward sensitivity were also assessed.

designThe study was a two-by-two factorial comparative observational design.

settingData were collected at baseline diagnostic visits as part of a neuroimaging study at a medical university in South Carolina, USA.

participantsTwenty-two BD + AD, 33 BD, 28 AD and 27 people without mental health problems participated. MEASUREMENTS: Diagnostic and clinician-rated symptom measures, self-report questionnaires and a computerized delay discounting task were administered. Two-by-two general linear univariate models were tested to examine between-group differences on discounting rates, and bivariate correlations and hierarchical regression analyses were performed to examine associations between discounting rates and self-reported reward sensitivity and impulsivity.

findingsThere was a significant main effect of AD (P = 0.006, η

conclusionsPeople with alcohol dependence appear to have higher delay discounting, while previously found associations between bipolar disorder and delay discounting may be secondary to alcohol use disorder.

Indexed as

Delay DiscountingImpulsive BehaviorRewardAdultAlcoholismBipolar DisorderCase-Control StudiesFemaleHumansMaleMiddle AgedSelf ReportSouth CarolinaAddictionalcohol use disorderbipolar disorderchoicedelay discountingdepressionimpulsivitymanicreward sensitivity

Identifiers

PMID30927381
PMCPMC6626565
OpenAlexW2929004936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.