Trial reportClinical transplantation2019
The impact of post-transplant diabetes mellitus on liver transplant outcomes.
Trial report in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Post-transplant diabetes mellitus requiring insulin identifies high-risk outcomes after solid organ transplantation.The Journal of clinical endocrinology and metabolism · 2026Article
- Article
- Screening and care of patients with graft cirrhosis following liver transplantation.Canadian liver journal · 2026Article
- Metabolic syndrome after liver transplantation: A silent threat to long-term success.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- Screening for Diabetes after Solid Organ Transplantation: A 10-Year Retrospective Study.EJIFCC · 2025Article
- Association of Sedentary Behavior and Physical Activity With the Risk of Post-Transplant Diabetes Mellitus Among Living Donor Liver Transplant Recipients: A Cross-Sectional Isotemporal Substitution Analysis.Clinical transplantation · 2025Article
- The mediating role of wellbeing in the relationship between health behaviors and quality of life in people with hepatogenous diabetes.Frontiers in public health · 2025Article
- Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation.World journal of hepatology · 2023Article
- Progress of new-onset diabetes after liver and kidney transplantation.Frontiers in endocrinology · 2023Review
- 2020 Clinical Update in Liver Transplantation.Journal of cardiothoracic and vascular anesthesia · 2022Review
- Risk factors associated with diabetes after liver transplant.Archives of endocrinology and metabolism · 2022Article
- Clinical implications of diabetes in chronic liver disease: Diagnosis, outcomes and management, current and future perspectives.World journal of gastroenterology · 2022Review
- Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- COVID-19 and liver disease: mechanistic and clinical perspectives.Nature reviews. Gastroenterology & hepatology · 2021Review
- A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation.Journal of clinical medicine · 2021Review
- Association between Liver Cirrhosis and Diabetes Mellitus: A Review on Hepatic Outcomes.Journal of clinical medicine · 2021Review
- Insight Into the Metabolomic Characteristics of Post-Transplant Diabetes Mellitus by the Integrated LC-MS and GC-MS Approach- Preliminary Study.Frontiers in endocrinology · 2021Article
- Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management.World journal of gastroenterology · 2020Review
- Peri-transplant management of nonalcoholic fatty liver disease in liver transplant candidates .Translational gastroenterology and hepatology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPost-transplant diabetes mellitus (PTDM) is common after liver transplantation (LT). Yet, how PTDM relates to graft outcomes and survival needs elucidation as more individuals are transplanted for nonalcoholic fatty liver disease (NAFLD).
methodsThis single-center, retrospective study of adult LT recipients (2003-2016) identified PTDM incidence and associations with graft steatosis, rejection, and post-LT patient survival. Multivariable analysis investigated predictors of PTDM. Kaplan-Meier curves depicted patient survival 5 years post-LT.
resultsAmong 415 adult LT recipients, 23% had pre-LT DM and 13% were transplanted for NAFLD. PTDM incidence was 34.7%, 46.9%, and 56.2% and overall survival was 90%, 80.9%, and 71.7% at 1, 3, and 5 years, respectively. Over a third of non-NAFLD patients developed PTDM. Half of PTDM cases developed by 6 months and 75% by 12 months. The PTDM group had more rejection episodes compared to no PTDM (31.9% vs 21.8%, P = 0.055), with trends toward worse patient survival 5 years post-LT (log-rank test P = 0.254). Age was the only significant predictor of PTDM.
conclusionsPost-transplant diabetes mellitus occurs rapidly in the post-LT period and is a significant problem for both NAFLD and non-NAFLD LT recipients. Age is a significant risk factor for PTDM. Outcomes trended toward increased rejection and worse survival among PTDM individuals, suggesting the benefit of early strategies targeting glucose control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.