Evidence map›Paper›PMID 30927254›Full record

ArticleBritish journal of pharmacology2019

Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels.

Jeffrey R McArthur, Rocio K Finol-Urdaneta, David J Adams

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  10. Inhibition of transient receptor potential vanilloid type 1 through αThe Journal of veterinary medical science · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeffrey R McArthurIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID 0000-0002-2546-7913
Rocio K Finol-UrdanetaIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID 0000-0003-2157-4532
David J AdamsIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID 0000-0002-7030-2288
University of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeT-type calcium (Ca EXPERIMENTAL APPROACH: Whole-cell patch clamp recordings were used to examine the effects of TRPV1-active compounds on rat dorsal root ganglion low voltage-activated calcium currents and recombinant Ca KEY

resultsThe classical TRPV1 agonist capsaicin as well as TRPV1 antagonists A-889425, BCTC, and capsazepine directly inhibited Ca CONCLUSIONS AND IMPLICATIONS: Analgesic TRPV1-active compounds inhibit Ca

Indexed as

AnalgesicsAnimalsCalcium Channel BlockersCalcium Channels, T-TypeCapsaicinDiterpenesGanglia, SpinalHEK293 CellsHumansNeuronsRats, Sprague-DawleyTRPV Cation ChannelsAnalgesicsCalcium Channel BlockersCalcium Channels, T-TypeCapsaicincapsazepineDiterpenesN-palmitoyl-vanillamideresiniferatoxinTRPV1 receptorTRPV Cation Channels

Identifiers

PMID30927254
PMCPMC6555866
OpenAlexW2928010947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.