Evidence map›Paper›PMID 30927239›Full record

ArticleJournal of community genetics2019

Linking pre-existing biorepositories for medical research: the PopGen 2.0 Network.

Wolfgang Lieb, Gunnar Jacobs, Andreas Wolf, Gesine Richter, Karoline I Gaede, Jeanette Schwarz, Norbert Arnold, Ruwen Böhm, Alena Buyx, Ingolf Cascorbi and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Wolfgang LiebInstitute of Epidemiology Kiel University and PopGen Biobank, University Hospital Schleswig-Holstein UKSH, Campus Kiel Hs. 1, Niemannsweg 11, 24105, Kiel, Germany. wolfgang.lieb@epi.uni-kiel.de.ORCID http://orcid.org/0000-0003-2544-4460
Gunnar JacobsInstitute of Epidemiology Kiel University and PopGen Biobank, University Hospital Schleswig-Holstein UKSH, Campus Kiel Hs. 1, Niemannsweg 11, 24105, Kiel, Germany.
Andreas WolfInstitute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Gesine RichterInstitute of Epidemiology Kiel University and PopGen Biobank, University Hospital Schleswig-Holstein UKSH, Campus Kiel Hs. 1, Niemannsweg 11, 24105, Kiel, Germany.
Karoline I GaedeBioMaterialBank Nord, Department of Medicine, Leibniz Lung Center for Medicine and Biosciences, Borstel, Germany.
Jeanette SchwarzInstitute of Clinical Chemistry, Kiel University, Kiel, Germany.
Norbert ArnoldInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Ruwen BöhmInstitute of Experimental and Clinical Pharmacology, Kiel University, Kiel, Germany.
Alena BuyxDivision of Biomedical Ethics, Institute of Experimental Medicine, Kiel University, Kiel, Germany.
Ingolf CascorbiInstitute of Experimental and Clinical Pharmacology, Kiel University, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Christine GlinickeEthics Committee of the Medical Faculty, University of Kiel, Kiel, Germany.
Janka Held-FeindtDepartment of Neurosurgery, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Ralf JunkerInstitute of Clinical Chemistry, Kiel University, Kiel, Germany.
Holger KalthoffInstitute for Experimental Cancer Research, Kiel University, Kiel, Germany.
Hans-Heiner KramerDepartment for Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Frank LeypoldtDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Nicolai MaassDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Walter MaetzlerDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Sandra MayInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
H Maximilian MehdornEthics Committee of the Medical Faculty, University of Kiel, Kiel, Germany.
Christoph RöckenInstitute of Pathology, Kiel University, Kiel, Germany.
Clemens SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Martin SchrappeDepartment of Pediatrics, University Hospital Schleswig-Holstein UKSH, Campus Kiel, Kiel, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Susanne SebensInstitute for Experimental Cancer Research, Kiel University, Kiel, Germany.
Ulrich StephaniDepartment of Neuropediatrics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Michael SynowitzDepartment of Neurosurgery, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Jörg WeimerDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
Peter ZabelDepartment of Pneumology, Leibniz Lung Center for Medicine and Biosciences, Borstel, Germany.
Ute NöthlingsDepartment of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.
Christian RöderInstitute of Epidemiology Kiel University and PopGen Biobank, University Hospital Schleswig-Holstein UKSH, Campus Kiel Hs. 1, Niemannsweg 11, 24105, Kiel, Germany.
Michael KrawczakInstitute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.

Funding

Bundesministerium für Bildung und Forschung 01EY1103
6 · The paper itself

Abstract

The significance of human biorepositories for modern medical research, particularly for comprehensive population-based genetic analyses, is constantly growing. While large and centralized institutions are usually considered best suited to meet the increasing demand for high-quality "biobanks," most medical research institutions still host rather heterogeneous and fragmented biobanking activities, undertaken by clinical departments with oftentimes rather different scientific scope. Undoubtedly, most clinicians and medical researchers would appreciate infrastructural support in terms of the storage and handling of their biosamples, but they are also likely to expect access to their samples avoiding extensive formal requirements. We report on the establishment of the PopGen 2.0 Network (P2N), an overarching alliance of initially seven biobanks from Northern Germany which adopted a joint but lean governance structure and use-and-access policy for their samples and data. In addition, the members of P2N have pursued an intense collaboration on ethical, legal and social issues and maintain a common IT infrastructure. The implementation of P2N has substantially improved the prospects of biobank-based research at the participating institutions. The network may thus serve as a role model for similar initiatives geared at linking pre-existing biorepositories for the benefit of research quality, efficiency, and transparency.

Indexed as

BiobankData managementEthicsGovernanceQuality assurance

Identifiers

PMID30927239
PMCPMC6754520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.