Individualized treatment of head neck squamous cell carcinoma patients aged 70 or older with radiotherapy alone or associated to cisplatin or cetuximab: impact of weekly radiation dose on loco-regional control.

Liliana Belgioia, Almalina Bacigalupo, Francesco Missale, Stefania Vecchio, Ilaria Chiola, Serena Callegari, Elisa Verzanini, Giorgio Peretti, Renzo Corvò

Abstract readComparative Study

PubMed Publisher

In one paragraph

Article in Medical oncology (Northwood, London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Radiotherapy for geriatric head-and-neck cancer patients: what is the value of standard treatment in the elderly?Radiation oncology (London, England) · 2020
Trial
Frailty and Overall Survival of Older Patients Undergoing Radiotherapy for Head and Neck Cancer: A Prospective Analysis.Cancers · 2024
Article
Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28- T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer.Cancers · 2021
Article
Narrative review of immunotherapy and radiation therapy in elderly patients.Translational cancer research · 2021
Review
Assessment of Predictive Scoring System for 90-Day Mortality Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Completed Concurrent Chemoradiotherapy.JAMA network open · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liliana BelgioiaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. liliana.belgioia@unige.it.ORCID http://orcid.org/0000-0003-0508-6344

Almalina BacigalupoRadiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID http://orcid.org/0000-0001-6875-5803

Francesco MissaleDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-5357-5348

Stefania VecchioMedical Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID http://orcid.org/0000-0002-6363-409X

Ilaria ChiolaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0001-6457-9021

Serena CallegariDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-2487-6205

Elisa VerzaniniDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0001-9263-9466

Giorgio PerettiDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0003-2362-8936

Renzo CorvòDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-5001-4844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to evaluate if, in elderly HNC patients, loco-regional control (LRC) is influenced by average weekly radiation dose (AWD). From 2009 to 2017, 150 consecutive HNC elderly patients were analyzed. AWD was calculated by dividing total dose in Gray by overall treatment time in weeks. Patients were divided in 2 groups: Group 1 (70-75 years) and Group 2 (> 75 years). Primary endpoint was LRC; secondary endpoints were overall survival (OS) and compliance to treatment. The median age was 76 years (range 70-92), the distribution of patients by age was 72 and 78 patients in Group 1 and in Group 2, respectively; overall median follow-up was 23 months. Optimal cut-off of AWD for LRC was 9.236 (p = 0.018). Median OS was 73 months. In univariate survival analysis low PS (p = 0.005), T3-T4 (p = 0.021), Stage III-IV (p = 0.046) and AWD

Indexed as

AgedAged, 80 and overCetuximabChemoradiotherapyCisplatinDisease ProgressionFemaleHead and Neck NeoplasmsHumansMalePatient ComplianceRadiation DosageRetrospective StudiesSquamous Cell Carcinoma of Head and NeckSurvival AnalysisCetuximabCisplatinAverage weekly doseChemoradiotherapyElderlyHead neck cancerLoco-regional controlRadical radiotherapy

Identifiers

PMID30927146

DOI10.1007/s12032-019-1264-2

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.