ArticlePlant cell reports2019
GCN5 modulates trichome initiation in Arabidopsis by manipulating histone acetylation of core trichome initiation regulator genes.
Article in Plant cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Structural innovation under environmental pressure: the evolutionary origins and regulatory mechanisms of thorns.Forestry research · 2026Review
- Comparative transcriptome analysis unravels distinct regulatory mechanisms governing fiber development in red silk cotton tree (Bombax ceiba).BMC plant biology · 2025Article
- Regulatory mechanisms of trichome and root hair development in Arabidopsis.Plant molecular biology · 2024Review
- Roles of Histone Acetylation and Deacetylation in Root Development.Plants (Basel, Switzerland) · 2024Review
- The transcription factor CAMTA2 interacts with the histone acetyltransferase GCN5 and regulates grain weight in wheat.The Plant cell · 2024Article
- Modulation of histone acetylation enables fully mechanized hybrid rice breeding.Nature plants · 2024Article
- Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review.Horticulture research · 2023Article
- Comparative Transcriptomic Analysis Revealed the Suppression and Alternative Splicing of Kiwifruit (International journal of molecular sciences · 2023Article
- Multi-Dimensional Molecular Regulation of Trichome Development inFrontiers in plant science · 2022Review
- Review
- The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants.Plants (Basel, Switzerland) · 2021Review
- Linking signaling pathways to histone acetylation dynamics in plants.Journal of experimental botany · 2020Review
- Integrated Analysis of mRNA and microRNA Elucidates the Regulation of Glycyrrhizic Acid Biosynthesis inInternational journal of molecular sciences · 2020Article
- The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome initiation inmicroPublication biology · 2019Article
- Expression of the DELLA repressor GAI and its regulators SPY and SEC are impacted by disruption of chromatin modifiers.microPublication biology · 2019Article
- GLABRA2, A Common Regulator for Epidermal Cell Fate Determination and Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2019Review
- Updates on molecular mechanisms in the development of branched trichome in Arabidopsis and nonbranched in cotton.Plant biotechnology journal · 2019Review
- The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves.Plants (Basel, Switzerland) · 2019Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
key messageHistone acetyltransferase GCN5 affects trichome initiation via mediating the expression of some core trichome initiation regulator genes in Arabidopsis. GENERAL CONTROL NON-REPRESSED PROTEIN5 (GCN5), a histone acetyltransferase involved in the regulation of cell differentiation, organ development, secondary metabolism, and plant responses to abiotic stresses, has recently been shown to modulate trichome branching in Arabidopsis. Here, we provide evidence that GCN5 is also involved in the regulation of trichome initiation. We found that mutation of GCN5 led to increased leaf trichome density in Arabidopsis. Quantitative RT-PCR results showed that the expression of CPC, GL1, GL2, and GL3, four well-known core trichome initiation regulator genes, was decreased in the gcn5 mutants. ChIP assays indicated that these four trichome initiation regulator genes are direct targets of GCN5. Consistent with these results, GCN5-mediated H3K14/K9 acetylation levels on the TSS regions of these genes were decreased. On the other hand, leaf trichome density was reduced in plants overexpressing GCN5, and both the transcript levels and GCN5-binding enrichments of CPC, GL1, GL2, and GL3 genes were elevated. Taken together, these data suggests that GCN5 affects trichome initiation by modulating the transcription activities of trichome initiation regulator genes via H3K9/14 acetylation.
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