ArticleExperimental brain research2019
Neurophysiological, neuropsychological, and cognitive effects of 30 days of isolation.
Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Art therapy and emotional pain: a scoping review of physiological and biological measures.Frontiers in human neuroscience · 2026Pooled it
- Robot therapy aids mental health in patients with hematological malignancy during hematopoietic stem cell transplantation in a protective isolation unit.Scientific reports · 2024Trial
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6.European journal of applied physiology · 2025Article
- Space Analogs and Behavioral Health Performance Research review and recommendations checklist from ESA Topical Team.NPJ microgravity · 2024Review
- Effects of Thirty Days Isolation on Attention Networks: A Behavioral and Event-related Potential Study.Neuroscience bulletin · 2024Article
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Short-term isolation effects on the brain, cognitive performance, and sleep-The role of exercise.Frontiers in physiology · 2023Article
- Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement.BMC neuroscience · 2022Article
- Global health emergencies during the pandemic and their solutionsTurkish journal of medical sciences · 2021Review
- Neuroimaging studies exploring the neural basis of social isolation.Epidemiology and psychiatric sciences · 2021Review
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Perception of the COVID-19 Pandemic Among Patients With Inflammatory Bowel Disease in the Time of Telemedicine: Cross-Sectional Questionnaire Study.Journal of medical Internet research · 2020Article
- Shifts in broadband power and alpha peak frequency observed during long-term isolation.Scientific reports · 2020Article
- Long-Term Impact of Social Isolation and Molecular Underpinnings.Frontiers in genetics · 2020Review
- Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day.BioMed research international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The increasing demand of space flights requires a profound knowledge of the chronologic reactions of the human body to extreme conditions. Prior studies already have shown the adverse effects of long-term isolation on psycho-physiological well-being. The chronology of the effects and whether short-term isolation periods already lead to similar effects has not been investigated. Therefore, the aim of the current study was to investigate the effects of short-term isolation (30 days) on mood, cognition, cortisol, neurotrophic factors, and brain activity. 16 participants were isolated in the Human Exploration Research Analog at NASA for 30 days. 17 non-isolated control participants were tested simultaneously. On mission days - 5, 7, 14, 28, and + 5, multiple tests including the Positive and Negative Affect Schedule-X and cognitive tests were conducted, and a 5-min resting electroencephalography was recorded. A fasted morning blood drawing was also done. Increased stress was observed via augmented cortisol levels during the isolation period. Activity within the parietal cortex was reduced over time, probably representing a neural adaptation to less external stimuli. Cognitive performance was not affected, but rather enhanced in both groups. No further significant changes in neurotrophic factors BDNF/IGF-1 and mood could be detected. These results suggest that 30 days of isolation do not have a significant impact on brain activity, neurotrophic factors, cognition, or mood, even though stress levels were significantly increased during isolation. Further studies need to address the question as to what extent increased levels of stress do not affect mental functions during isolation periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.