Polymer translocation through a hairy channel mimicking the inner plug of a nuclear pore complex.

Chibin Zhang, Zhiwei Cheng, Xiaohui Lin, Wenquan Chu

Abstract read

In one paragraph

Article in European biophysics journal : EBJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chibin ZhangSchool of Mechanical Engineering, Southeast University, 2 Southeast Road, Jiangning District, Nanjing, 211189, China. chibinchang@aliyun.com.ORCID http://orcid.org/0000-0003-1493-1079

Zhiwei ChengSchool of Mechanical Engineering, Southeast University, 2 Southeast Road, Jiangning District, Nanjing, 211189, China.

Xiaohui LinSchool of Mechanical Engineering, Southeast University, 2 Southeast Road, Jiangning District, Nanjing, 211189, China.

Wenquan ChuSchool of Mechanical Engineering, Southeast University, 2 Southeast Road, Jiangning District, Nanjing, 211189, China.

Funding

National Natural Science Foundation of China 51375090

6 · The paper itself

Abstract

A microscopic transport model of a polymer translocating through a nuclear pore complex (NPC) is presented based on self-consistent field theory (SCFT), with the NPC and its nucleoporins mimicked by a hairy channel. Multiple cell environment effects (electrolyte effect, excluded volume effect, NPC drag effect, and hydrophobic effect) are all considered in this hairy channel model. The influence of various parameters (polymer chain length, length of NPC, strength of hydrophobic effect, and excluded volume effect) on translocation time is studied through theoretical analysis and numerical calculation. Numerical simulation results show that an area of low nucleoporin number density exists in the NPC, which facilitates the translocation of the polymer. The results also show that the translocation time curves with increasing NPC length and polymer charge number are concave. In addition, there are critical values for NPC length and polymer charge number for which the translocation time has a minimal value. The translocation time decreases with the increasing strength of the hydrophobic effect and excluded volume effect.

Indexed as

Models, BiologicalCytoplasmDiffusionHydrophobic and Hydrophilic InteractionsNuclear PorePolymersThermodynamicsPolymersNuclear pore complexPolymerSelf-consistent field theoryTranslocation time

Identifiers

PMID30927020

DOI10.1371/journal.pcbi.0030125

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.