ArticleSchizophrenia bulletin2019
Connectome-Based Patterns of First-Episode Medication-Naïve Patients With Schizophrenia.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Impaired regional structure-function coupling as novel neurophenotype: mechanistic insights and diagnostic exploration in treatment-resistant depression.Npj mental health research · 2026Article
- Observational
- Harmonizing network-based statistics across different atlases in brain connectome analysis.Communications biology · 2025Article
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- The modular mind and psychiatry: toward clinical integration with a focus on self-disorders.Frontiers in psychology · 2025Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia.Biological psychiatry global open science · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Effects of second language acquisition on brain functional networks at different developmental stages.Brain imaging and behavior · 2024Article
- Distinct brain network patterns in complete and incomplete spinal cord injury patients based on graph theory analysis.CNS neuroscience & therapeutics · 2024Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Review
- Brain tissue segmentation in neurosurgery: a systematic analysis for quantitative tractography approaches.Acta neurologica Belgica · 2024Review
- Transcriptomic and neuroimaging data integration enhances machine learning classification of schizophrenia.Psychoradiology · 2024Article
- Cortical Network Disruption Is Minimal in Early Stages of Psychosis.Schizophrenia bulletin open · 2024Article
- Peak width of skeletonized mean diffusivity as a neuroimaging biomarker in first-episode schizophrenia.Frontiers in neuroscience · 2024Article
- Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia.BMC medicine · 2023Article
- Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Schizophrenia research · 2023Article
- Abnormal Structural Network Communication Reflects Cognitive Deficits in Schizophrenia.Brain topography · 2023Article
- Negative symptoms are associated with modularity and thalamic connectivity in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Emerging evidence indicates that a disruption in brain network organization may play an important role in the pathophysiology of schizophrenia. The neuroimaging fingerprint reflecting the pathophysiology of first-episode schizophrenia remains to be identified. Here, we aimed at characterizing the connectome organization of first-episode medication-naïve patients with schizophrenia. A cross-sectional structural and functional neuroimaging study using two independent samples (principal dataset including 42 medication-naïve, previously untreated patients and 48 healthy controls; replication dataset including 39 first-episode patients [10 untreated patients] and 66 healthy controls) was performed. Brain network architecture was assessed by means of white matter fiber integrity measures derived from diffusion-weighted imaging (DWI) and by means of structural-functional (SC-FC) coupling measured by combining DWI and resting-state functional magnetic resonance imaging. Connectome rich club organization was found to be significantly disrupted in medication-naïve patients as compared with healthy controls (P = .012, uncorrected), with rich club connection strength (P = .032, uncorrected) and SC-FC coupling (P < .001, corrected for false discovery rate) decreased in patients. Similar results were found in the replication dataset. Our findings suggest that a disruption of rich club organization and functional dynamics may reflect an early feature of schizophrenia pathophysiology. These findings add to our understanding of the neuropathological mechanisms of schizophrenia and provide new insights into the early stages of the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.