Evidence map›Paper›PMID 30926973›Full record

SynthesisNature genetics2019

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Amy R Bentley, Yun J Sung, Michael R Brown, Thomas W Winkler, Aldi T Kraja, Ioanna Ntalla, Karen Schwander, Daniel I Chasman, Elise Lim, Xuan Deng and 295 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

305 authors.

Amy R Bentley *Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. amy.bentley@nih.gov.ORCID http://orcid.org/0000-0002-0827-9101
Yun J Sung *Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Michael R Brown *Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Thomas W Winkler *Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Aldi T Kraja *Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ioanna Ntalla *Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Elise LimDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Xuan DengDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jingmin LiuWomen's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yingchang LuCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1233-7642
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jennifer E HuffmanMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9672-2491
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Changwei LiEpidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Melissa A RichardBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0129-9860
Raymond NoordamInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Jenna BakerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Hugues AschardCentre de Bioinformatique, Biostatistique, et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
Traci M BartzCardiovascular Health Research Unit, Department of Biostatistics, University of Washington, Seattle, WA, USA.
Jingzhong DingCenter on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6608-2051
Alisa K ManningClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0247-902X
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Salman M TajuddinHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7919-8528
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Maris AlverEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mathilde BoisselCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0001-5719-8749
Jin Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7299-3238
Jasmin DiversDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.ORCID http://orcid.org/0000-0002-5488-2999
Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Anuj GoelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2307-4021
Yanick HagemeijerUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-6036-3741
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Fernando P HartwigPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.ORCID http://orcid.org/0000-0003-3729-0710
Meian HeDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Andrea R V R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Fang-Chi HsuDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yi-Jen HungEndocrinology and Metabolism, Tri-Service General Hospital, Taipei, Taiwan.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9672-2547
Anuradhani KasturiratneDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Pirjo KomulainenFoundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Karin LeanderUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Keng-Hung LinOphthalmology, Taichung Veterans General Hospital, Taichung, Taiwan.
Jian'an LuanMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Nana MatobaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-5329-0134
Ilja M NolteUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Maik PietznerDZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.
Bram PrinsHuman Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Muhammad RiazDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Antonietta RobinoInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
M Abdullah SaidUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.
Robert A ScottMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
Tamar SoferDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Alena StancákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3185-5661
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Peter J van der MostUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.ORCID http://orcid.org/0000-0002-2383-699X
Tzung-Dau WangCardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-7180-3607
Yajuan WangDepartment of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4731-8158
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Yong-Bing XiangSKLORG and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Lisa R YanekDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Weihua ZhangMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Jing Hua ZhaoMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3105-3231
Saima AfaqMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Marzyeh AminiUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zorayr ArzumanyanInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Christie BallantyneSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Departments of Pediatrics, Medicine, and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Morris BrownClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1424-0673
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0002-3396-4549
Sabanayagam CharumathiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4042-4719
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kaare ChristensenDanish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
COGENT-Kidney Consortium
Maria Pina ConcasInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.ORCID http://orcid.org/0000-0003-3598-2537
John M ConnellNinewells Hospital and Medical School, University of Dundee, Dundee, UK.
Lisa de las FuentesDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-4689-325X
H Janaka de SilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ayo DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Qing DuanDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Charles B EatonDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USA.
Ruben N EppingaUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
James S FloydCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Nita G ForouhiMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5041-248X
Terrence ForresterUWI Solutions for Developing Countries, University of the West Indies, Kingston, Jamaica.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Ilaria GandinDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
He GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9476-7143
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA.
Bruna GiganteUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA.
Sami HeikkinenInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7309-9473
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Minato-ku, Japan.ORCID http://orcid.org/0000-0002-9994-9958
James E HixsonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
EPIC-InterAct Consortium
Yucheng JiaInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Roby JoehanesHebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5549-9054
Craig JohnsonCollaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.
Jost Bruno JonasDepartment of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-2972-5227
Anne E JusticeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8903-8712
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Ivana KolcicDepartment of Public Health, Department of Medicine, University of Split, Split, Croatia.
Charles KooperbergFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5464-1792
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Timo A LakkaFoundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Carl D LangefeldDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Claudia LangenbergMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5017-7344
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA.
Benjamin LehneInstitute of Clinical Sciences, Department of Molecular Sciences, Imperial College, London, UK.
Cora E LewisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Yize LiDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Jingjing LiangDepartment of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Shiow LinDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3255-3019
Kiang LiuEpidemiology, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Marie LohMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Kurt K LohmanDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Anna LuzziInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Ani W ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Colin A McKenzieTropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, Jamaica.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
Lili MilaniEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Karen L MohlkeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6721-153X
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Andrew P MorrisWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6805-6014
Alison D MurrayInstitute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0003-4915-4847
Mike A NallsData Tecnica International, Glen Echo, MD, USA.
Matthias NauckDZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
George J PapanicolauEpidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ozren PolasekDepartment of Public Health, Department of Medicine, University of Split, Split, Croatia.
Neil PoulterSchool of Public Health, Imperial College, London, UK.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Alex P ReinerFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Jennifer G RobinsonDepartment of Epidemiology and Medicine, University of Iowa, Iowa City, IA, USA.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Frits R RosendaalClinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6993-6884
Carsten O SchmidtInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Pamela J SchreinerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
William R ScottInstitute of Clinical Sciences, Department of Molecular Sciences, Imperial College, London, UK.
Peter SeverNational Heart and Lung Institute, Imperial College, London, UK.
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Konstantin StrauchGenetic Epidemiology, Faculty of Medicine, Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig Maximilian University, Munich, Germany.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2991-6392
Nicholas Y Q TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Hua TangDepartment of Genetics, Stanford University, Stanford, CA, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yik Ying TeoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Henning TiemeierDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-4395-1397
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Understanding Society Scientific Group
Diana van HeemstInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Heming WangDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Lan WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Wen Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Christine A WilliamsDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Gregory WilsonJackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USA.
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kristin YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0070-6145
Caizheng YuDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jian-Min YuanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4620-3108
Jie ZhouCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA.
Diane M BeckerDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Donald W BowdenBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Richard S CooperDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Ulf de FaireUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Paul ElliottMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.ORCID http://orcid.org/0000-0002-7511-5684
Tõnu EskoEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1982-6569
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Barry I FreedmanNephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-2972-0784
Paolo GaspariniInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Christian GiegerInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Bernardo L HortaPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.ORCID http://orcid.org/0000-0001-9843-412X
Jyh-Ming Jimmy JuangNational Taiwan University College of Medicine, Taipei, Taiwan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Candace M KammererDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2841-4761
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Jaspal S KoonerMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
I-Te LeeEndocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Lifelines Cohort
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Albertine J OldehinkelUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Rainer RauramaaFoundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
James ScottNational Heart and Lung Institute, Imperial College, London, UK.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jun-Sing WangEndocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2749-7793
Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Tangchun WuDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Eleftheria ZegginiHuman Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Yongmei LiuPublic Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Dennis O Mook-KanamoriClinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Tanika N KellyEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Ervin R FoxCardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiaofeng ZhuDepartment of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Laura J BierutPsychiatry, Washington University School of Medicine, St. Louis, MO, USA.
W James GaudermanBiostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Kenneth Rice *Department of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Patricia B Munroe *Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-4176-2947
Alanna C Morrison *Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Dabeeru C Rao *Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Charles N Rotimi *Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. rotimic@mail.nih.gov.ORCID http://orcid.org/0000-0001-5759-053X
L Adrienne Cupples *Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.ORCID http://orcid.org/0000-0003-0273-7965

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
Biotechnology and Biological Sciences Research Council BB/F019394/1Intramural NIH HHS Z01 HG200362Intramural NIH HHS Z99 HG999999Intramural NIH HHS ZIA HG200362Medical Research Council MC_U106179471Medical Research Council MC_UP_1605/7Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MR/K002414/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/R023484/1NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS U01 CA182913NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182910NHLBI NIH HHS K01 HL135405NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R35 HL135818NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL137162NIA NIH HHS R01 AG060110NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG023746NICHD NIH HHS P2C HD050924NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK117445NIDDK NIH HHS U01 DK062370NIEHS NIH HHS P30 ES007048NIMHD NIH HHS R01 MD012765Wellcome Trust 212945/Z/18/Z
6 · The paper itself

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Indexed as

AdolescentAdultAgedAged, 80 and overFemaleGenome-Wide Association StudyGenotypeHumansLife StyleLinkage DisequilibriumLipidsMaleMiddle AgedSmokingYoung AdultLipids

Identifiers

PMID30926973
PMCPMC6467258

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