Evidence map›Paper›PMID 30926903›Full record

ArticleScientific reports2019

Protein kinase CK2-dependent aerobic glycolysis-induced lactate dehydrogenase A enhances the migration and invasion of cancer cells.

Dae-Kyun Im, Heesun Cheong, Jong Suk Lee, Min-Kyu Oh, Kyung Mi Yang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Metabolic Strategies for Inhibiting Cancer Development.Advances in nutrition (Bethesda, Md.) · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. FX11 limitsDisease models & mechanisms · 2020
    Article
  14. Protein Kinase CK2 in Cancer Energetics.Frontiers in oncology · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Dae-Kyun ImDepartment of Chemical and Biological Engineering, Korea University, Seoul, 02841, Korea.
Heesun CheongDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea.
Jong Suk LeeBiocenter, Gyeonggido Business and Science Accelerator (GBSA), Suwon, Gyeonggi-do, 16229, Republic of Korea.
Min-Kyu OhDepartment of Chemical and Biological Engineering, Korea University, Seoul, 02841, Korea. mkoh@korea.ac.kr.
Kyung Mi YangDepartment of Biochemistry and Molecular Biology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. kyungmi.yang@gmail.com.ORCID http://orcid.org/0000-0002-0403-8247
Korea University · KRBio-Medical Science (South Korea) · KRNational Cancer Center · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the intracellular metabolic fluxes of protein kinase CK2-activating (Cα OE) cells and role of lactate dehydrogenase A (LDHA) as a contributor of tumorigenesis after reprogrammed glucose metabolism. Facilitated aerobic glycolysis was confirmed via isotope tracer analysis, in which

Indexed as

AerobiosisAnimalsCasein Kinase IICell CycleCell Line, TumorCell MovementCell ProliferationCitric Acid CycleGlucoseGlycolysisHumansLactate DehydrogenasesMiceNeoplasmsPyruvic AcidXenograft Model Antitumor AssaysCasein Kinase IICSNK2A1 protein, humanGlucoseLactate DehydrogenasesPyruvic Acid

Identifiers

PMID30926903
PMCPMC6441004
OpenAlexW2924369475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.