ArticleNature communications2019
The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 114 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
114 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis.The Lancet. Global health · 2023Pooled it
- Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Global patterns of submicroscopicThe Lancet. Microbe · 2021Pooled it
- Trial
- Effectiveness of reactive focal mass drug administration and reactive focal vector control to reduce malaria transmission in the low malaria-endemic setting of Namibia: a cluster-randomised controlled, open-label, two-by-two factorial design trial.Lancet (London, England) · 2020Trial
- Prevalence and risk factors of asymptomatic Plasmodium spp. infection in the military population of the Colombian National Army.PLoS neglected tropical diseases · 2026Article
- Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania.Infectious diseases of poverty · 2026Article
- Asymptomatic school-age children carry the majority of transmissible Plasmodium falciparum infections.Communications medicine · 2026Article
- Spatiotemporal trends in P. falciparum malaria and identification of high-risk villages in Eastern Myanmar: an 8-year observational study.Scientific reports · 2025Observational
- Community engagement in mass drug administration participatory interventions: A scoping review.PLoS neglected tropical diseases · 2025Article
- Determinants of locally acquired malaria infections in Zanzibar: a cross-sectional study.Malaria journal · 2025Article
- Remoscope: a label-free imaging cytometer for malaria diagnostics.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Patterns of patent and sub-patent Plasmodium falciparum infections in household members of children under seasonal malaria chemoprevention coverage in the health district of Nanoro, Burkina Faso.Malaria journal · 2025Article
- Marked heterogeneity in malaria infection rate in a Malian longitudinal cohort.Nature communications · 2025Article
- Article
- Off-grid field-deployable molecular diagnostic platform for malaria surveillance.Parasites & vectors · 2025Article
- The burden and diagnostic challenges of subclinical Plasmodium falciparum infections in Southern Ghana.BMC infectious diseases · 2025Article
- [SubmicroscopicMedecine tropicale et sante internationale · 2025Article
- Prevalence of subpatent Plasmodium falciparum infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania.Malaria journal · 2025Article
- Submicroscopic malaria in pregnancy and associated adverse pregnancy events: A case-cohort study of 4,352 women on the Thailand-Myanmar border.PLoS medicine · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
41 authors.
Funding
Abstract
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.