Evidence map›Paper›PMID 30926877›Full record

ArticleScientific reports2019

Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.

Luka Brčić, Ana Barić, Sanda Gračan, Vesela Torlak, Marko Brekalo, Veselin Škrabić, Tatijana Zemunik, Maja Barbalić, Ante Punda, Vesna Boraska Perica

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luka BrčićDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.
Ana BarićDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Sanda GračanDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Vesela TorlakDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Marko BrekaloDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Veselin ŠkrabićDepartment of Pediatrics, University Hospital Split, Split, Croatia.
Tatijana ZemunikDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.
Maja BarbalićDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.
Ante PundaDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Vesna Boraska PericaDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia. vboraska@mefst.hr.
University of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto's thyroiditis (HT), the most common autoimmune thyroid disorder. Genetic determinants of thyroid antibodies are still poorly known, especially as they were not studied in patients with thyroid diseases. We performed the first genome-wide association analysis of thyroid antibodies in 430 HT patients that may be considered as population extremes for thyroid antibodies distribution. We detected two suggestively associated genetic variants with TgAb, rs6972286 close to ANKRD7 and LSM8 (P = 2.34 × 10

Indexed as

Genetic LociGenome-Wide Association StudyAdultAutoantibodiesBiomarkersFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationHashimoto DiseaseHumansMaleMiddle AgedThyroid GlandAutoantibodiesBiomarkers

Identifiers

PMID30926877
PMCPMC6440971
OpenAlexW2931202732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.