Evidence map›Paper›PMID 30926815›Full record

ArticleNature communications2019

Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc

Elizabeth Calzada, Erica Avery, Pingdewinde N Sam, Arnab Modak, Chunyan Wang, J Michael McCaffery, Xianlin Han, Nathan N Alder, Steven M Claypool

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Article
  3. Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality.Protein science : a publication of the Protein Society · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elizabeth CalzadaDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Erica AveryDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pingdewinde N SamDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arnab ModakDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Chunyan WangBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
J Michael McCafferyIntegrated Imaging Center, Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
Xianlin HanBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-8615-2413
Nathan N AlderDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Steven M ClaypoolDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sclaypo1@jhmi.edu.ORCID http://orcid.org/0000-0001-5316-1623
Johns Hopkins University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Connecticut · US

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETER J HORNSBY · 1995 to 2026
$30.6M
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Mitochondrial phosphatidylethanolamine metabolismR01GM111548 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CLAYPOOL, STEVEN MICHAEL · 2014 to 2021
$2.8M
Investigation of the Subunit and Lipid Interactions of the Mitochondrial Protein Import MachineryR01GM113092 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI ALDER, NATHAN N · 2015 to 2019
$1.5M
NIA NIH HHS P30 AG013319NIGMS NIH HHS R01 GM111548NIGMS NIH HHS R01 GM113092NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Of the four separate PE biosynthetic pathways in eukaryotes, one occurs in the mitochondrial inner membrane (IM) and is executed by phosphatidylserine decarboxylase (Psd1). Deletion of Psd1 is lethal in mice and compromises mitochondrial function. We hypothesize that this reflects inefficient import of non-mitochondrial PE into the IM. Here, we test this by re-wiring PE metabolism in yeast by re-directing Psd1 to the outer mitochondrial membrane or the endomembrane system and show that PE can cross the IMS in both directions. Nonetheless, PE synthesis in the IM is critical for cytochrome bc

Indexed as

AerobiosisElectron Transport Complex IIIElectron Transport Complex IVEndoplasmic ReticulumMitochondrial MembranesMutationPhosphatidylethanolaminesReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsElectron Transport Complex IIIElectron Transport Complex IVphosphatidylethanolaminePhosphatidylethanolaminesSaccharomyces cerevisiae Proteins

Identifiers

PMID30926815
PMCPMC6441012
OpenAlexW2949688841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.