ArticleNature communications2019
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
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84citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
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Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- A genetic profiling guideline to support diagnosis and clinical management of lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Guideline
- Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.The New England journal of medicine · 2020Trial
- Genomic architecture of IRF4 rearrangements in childhood and adult large B-cell lymphomas.Blood advances · 2026Article
- The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B-BCL6 Regulatory Circuit in Burkitt Lymphoma.International journal of cancer · 2026Article
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- Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.Nature immunology · 2026Article
- Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma.Nature communications · 2026Article
- [Analysis of the disease burden of Burkitt lymphoma in China from 1990 to 2021].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Article
- Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.Cancers · 2026Review
- miRNA profiling in pediatric and young adult Burkitt leukemia and lymphoma.Virchows Archiv : an international journal of pathology · 2026Article
- Proteomic analysis of Burkitt lymphoma tissues: insights into the impact of age and EBV infection on protein expression and molecular characteristics.Discover oncology · 2025Article
- "In situ" MYC rearrangement and amplification as a secondary change in a case of High-grade B cell lymphoma with 11q aberration.Annals of hematology · 2025Article
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- HNRNPH1-mediated splicing events regulatebioRxiv : the preprint server for biology · 2025Article
- Genomic landscape of virus-associated cancers.Nature communications · 2025Article
- B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements.Blood cancer discovery · 2025Article
- Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules.Leukemia · 2025Article
- Subtyping Burkitt Lymphoma by DNA Methylation.Genes, chromosomes & cancer · 2025Article
- Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
57 authors at 20 institutions in 2 countries.
Cristina LópezInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.ORCID http://orcid.org/0000-0001-6644-1659
Kortine KleinheinzDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1859-2281
Sietse M AukemaInstitute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
Marius RohdePediatric Hematology and Oncology, University Hospital Giessen, 35392, Giessen, Germany.
Stephan H BernhartInterdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
Daniel HübschmannDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Rabea WagenerInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
Umut H ToprakDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Francesco RaimondiCell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg, 69120, Heidelberg, Germany.
Markus KreuzInstitute for Medical Informatics Statistics and Epidemiology, 04107, Leipzig, Germany.
Sebastian M WaszakGenome Biology Unit, EMBL Heidelberg, 69117, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3042-9521
Zhiqin HuangDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Lina SieverlingFaculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
Nagarajan ParamasivamDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Julian SeufertBioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Stephanie SungaleeGenome Biology Unit, EMBL Heidelberg, 69117, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5633-8826
Robert B RussellCell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1905-4717
Julia BausingerInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
Helene KretzmerInterdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
Ole AmmerpohlInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
Anke K BergmannInstitute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
Hans BinderInterdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
Arndt BorkhardtMedical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-6121-4737
Benedikt BrorsDivision of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5940-3101
Alexander ClaviezDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
Gero DooseInterdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
Lars FeuerbachDivision of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Andrea HaakeInstitute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
Martin-Leo HansmannSenckenberg Institute of Pathology, University of Frankfurt Medical School, 60590, Frankfurt am Main, Germany.
Jessica HoellMedical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Michael HummelInstitute of Pathology, Charité - University Medicine Berlin, 10117, Berlin, Germany.
Jan O KorbelGenome Biology Unit, EMBL Heidelberg, 69117, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2798-3794
Chris LawerenzDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Dido LenzeInstitute of Pathology, Charité - University Medicine Berlin, 10117, Berlin, Germany.
Bernhard RadlwimmerDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Julia RichterInstitute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.ORCID http://orcid.org/0000-0002-9543-4084
Philip RosenstielInstitute of Clinical Molecular Biology, Christian-Albrechts-University, 24105, Kiel, Germany.
Andreas RosenwaldInstitute of Pathology, Comprehensive Cancer Center Mainfranken, University of Würzburg, 97080, Würzburg, Germany.
Markus B SchilhabelInstitute of Clinical Molecular Biology, Christian-Albrechts-University, 24105, Kiel, Germany.
Harald SteinPathodiagnostik Berlin, 12099, Berlin, Germany.
Stephan StilgenbauerDepartment for Internal Medicine III, Ulm University, 89081, Ulm, Germany.
Peter F StadlerBioinformatics Group, Department of Computer, University of Leipzig, 04107, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5016-5191
Monika SzczepanowskiHematopathology Section, Christian-Albrechts-University, 24105, Kiel, Germany.
Marc A WenigerInstitute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, 45147, Essen, Germany.
Marc ZapatkaDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8287-5967
Roland EilsDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0034-4036
Peter LichterDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Markus LoefflerInstitute for Medical Informatics Statistics and Epidemiology, 04107, Leipzig, Germany.
Peter MöllerInstitute of Pathology, University of Ulm and University Hospital of Ulm, 89081, Ulm, Germany.
Lorenz TrümperDepartment of Hematology and Oncology, Georg-August-University of Göttingen, 37075, Göttingen, Germany.
Wolfram KlapperHematopathology Section, Christian-Albrechts-University, 24105, Kiel, Germany.
ICGC MMML-Seq Consortium
Steve HoffmannInterdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
Ralf KüppersInstitute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, 45147, Essen, Germany.ORCID http://orcid.org/0000-0002-6691-7191
Birgit BurkhardtUniversity Hospital Münster - Pediatric Hematology and Oncology, 48149, Münster, Germany.
Matthias SchlesnerDivision of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. m.schlesner@Dkfz-Heidelberg.de.ORCID http://orcid.org/0000-0002-5896-4086
Reiner SiebertInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany. reiner.siebert@uni-ulm.de.
German Cancer Research Center · DEChristian-Albrechts-Universität zu Kiel · DEUniversität Ulm · DELeipzig University · DEUniversity of Göttingen · DEUniversity of Würzburg · DEEuropean Molecular Biology Organization · DEHeinrich Heine University Düsseldorf · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEClinical Research Center Kiel · DEFriedrich-Ebert-Krankenhaus · DEHeidelberg University · DEUniversity Hospital Münster · DEUniversity of Duisburg-Essen · DEGoethe University Frankfurt · DEHelios Dr. Horst Schmidt Kliniken Wiesbaden · DEKlinikum St. Georg · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEMax Planck Institute for Molecular Genetics · DENational Center for Tumor Diseases · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing.
Indexed as
Genome, HumanAdolescentAlternative SplicingAmino Acid SequenceBasic Helix-Loop-Helix ProteinsBurkitt LymphomaChildChild, PreschoolChromosome BreakpointsCohort StudiesDNA MethylationDNA Mutational AnalysisFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansBasic Helix-Loop-Helix ProteinsOncogene Proteins, FusionProto-Oncogene Proteins c-mycTCF3 protein, human
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