Evidence map›Paper›PMID 30926745›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.

Yang Zhong Huang, Xiao-Ping He, Kamesh Krishnamurthy, James O McNamara

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of neurotrophic factors in novel, rapid psychiatric treatments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  4. Article
  5. Review
  6. Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Yang Zhong HuangDepartments of Neurobiology.ORCID 0000-0002-4770-1694
Xiao-Ping HeDepartments of Neurobiology.
Kamesh KrishnamurthyDepartments of Neurobiology.
James O McNamaraDepartments of Neurobiology, jmc@neuro.duke.edu.
Institute of Neurobiology · BGDuke Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Neurotrophins and EpileptogenesisR01NS056217 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2006 to 2023
$6.7M
Cellular and Circuit Mechanisms of Temporal Lobe EpilepsyR01NS097717 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2017 to 2021
$2.2M
NIGMS NIH HHS T32 GM007171NINDS NIH HHS R01 NS056217NINDS NIH HHS R01 NS097717
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of

Indexed as

AnimalsBinding SitesBrain-Derived Neurotrophic FactorCell DifferentiationCells, CulturedCell SurvivalHedgehog ProteinsHippocampusMAP Kinase Signaling SystemMechanotransduction, CellularMembrane GlycoproteinsMiceMutagenesis, Site-DirectedNerve Growth FactorsNerve Tissue ProteinsPhosphorylationBrain-Derived Neurotrophic FactorHedgehog ProteinsMembrane GlycoproteinsNerve Growth FactorsNerve Tissue Proteinsneurotrophin 4Ntrk2 protein, mouseProtein-Tyrosine KinasesReceptor, trkBRecombinant ProteinsShh protein, mousehippocampusneuroprotectionShcstatus epilepticustemporal lobe epilepsyTrkB

Identifiers

PMID30926745
PMCPMC6554629
OpenAlexW2928040144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.