Evidence map›Paper›PMID 30926671›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression.

Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yueqi Zhu, Zhou Yang and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 101 citations in OpenAlex.

  1. Review
  2. Review
  3. A Machine Vision Perspective on Droplet-Based Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Bioinspired Confined Assembly of Cellulosic Cholesteric Liquid Crystal Bubbles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Hongbo ZhangBeijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
Wenguo CuiHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
Xiangmeng QuBeijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
Huayin WuHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-3258-4314
Liangliang QuBeijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
Xu ZhangHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
Ermei MäkiläLaboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014 Turku, Finland.
Jarno SalonenLaboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014 Turku, Finland.
Yueqi ZhuDepartment of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, People's Republic of China; zhuyueqi@hotmail.com mingtanhai@mater.ustb.edu.cn weitz@seas.harvard.edu.
Zhou YangBeijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
Dong ChenHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
Hélder A SantosDivision of Pharmaceutical Chemistry and Technology, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0001-7850-6309
Mingtan HaiBeijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China; zhuyueqi@hotmail.com mingtanhai@mater.ustb.edu.cn weitz@seas.harvard.edu.
David A WeitzHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; zhuyueqi@hotmail.com mingtanhai@mater.ustb.edu.cn weitz@seas.harvard.edu.
Harvard University · USÅbo Akademi University · FIShanghai Jiao Tong University · CNUniversity of Helsinki · FIUniversity of Science and Technology Beijing · CNUniversity of Turku · FI

Funding

MSC Encapsulation with Thin Gel CoatingR01EB023287 · NIBIB · HARVARD UNIVERSITY · PI MOONEY, DAVID J, SCADDEN, DAVID T · 2017 to 2019
$2.0M
NIBIB NIH HHS R01 EB023287
6 · The paper itself

Abstract

Effective cancer therapies often demand delivery of combinations of drugs to inhibit multidrug resistance through synergism, and the development of multifunctional nanovehicles with enhanced drug loading and delivery efficiency for combination therapy is currently a major challenge in nanotechnology. However, such combinations are more challenging to administer than single drugs and can require multipronged approaches to delivery. In addition to being stable and biodegradable, vehicles for such therapies must be compatible with both hydrophobic and hydrophilic drugs, and release drugs at sustained therapeutic levels. Here, we report synthesis of porous silicon nanoparticles conjugated with gold nanorods [composite nanoparticles (cNPs)] and encapsulate them within a hybrid polymersome using double-emulsion templates on a microfluidic chip to create a versatile nanovehicle. This nanovehicle has high loading capacities for both hydrophobic and hydrophilic drugs, and improves drug delivery efficiency by accumulating at the tumor after i.v. injection in mice. Importantly, a triple-drug combination suppresses breast tumors by 94% and 87% at total dosages of 5 and 2.5 mg/kg, respectively, through synergy. Moreover, the cNPs retain their photothermal properties, which can be used to significantly inhibit multidrug resistance upon near-infrared laser irradiation. Overall, this work shows that our nanovehicle has great potential as a drug codelivery nanoplatform for effective combination therapy that is adaptable to other cancer types and to molecular targets associated with disease progression.

Indexed as

Antineoplastic AgentsNanotubesAnimalsDrug Delivery SystemsFemaleGoldHydrophobic and Hydrophilic InteractionsMiceMice, NudeMicrofluidic Analytical TechniquesNanomedicineNeoplasms, ExperimentalPhotochemical ProcessesPorositySiliconAntineoplastic AgentsGoldSiliconcancer therapydrug deliverymicrofluidicsnanomaterials

Identifiers

PMID30926671
PMCPMC6475426
OpenAlexW2931657978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.