Evidence map›Paper›PMID 30926654›Full record

ArticleGut2019

Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study.

Quancai Cai, Chunping Zhu, Yuan Yuan, Qi Feng, Yichao Feng, Yingxia Hao, Jichang Li, Kaiguang Zhang, Guoliang Ye, Liping Ye and 21 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyValidation Study
In one paragraph

Article in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04986215 (Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy), which is not on this map. Cited by 123 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 3 pooled it
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04986215 unknown statusnot on this mapstarted 2020, after this paper: background citation

Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy

TypeobservationalSponsorChanghai HospitalRan2020 to 2023Enrolled300ConditionsPancreatic Space Occupying
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 3 syntheses or guidelines pooled it, 215 citations in OpenAlex.

  1. Diagnostic Risk Prediction Models for Upper Gastrointestinal Cancers: A Systematic Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Comprehensive analysis of the gastric metatranscriptome reveals specific viral signatures associated with gastric cancer.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  7. Article
  8. Review
  9. Plasma proteomic signatures improve risk stratification and personalized screening for gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Systemic serological signatures and novel biomarker CST4 link CagA-positiveFrontiers in cellular and infection microbiology · 2026
    Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 1 country.

Quancai Cai *Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Chunping Zhu *Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Yuan Yuan *Tumor Etiology and Screening Department, China Medical University, Shenyang, China.
Qi FengDepartment of Gastroenterology, Mianyang Central Hospital, Mianyang, China.
Yichao FengDepartment of Gastroenterology, Affiliated Hospital of Yan'an University, Yanan, China.
Yingxia HaoDepartment of Gastroenterology, Baoding First Central Hospital, Baoding, China.
Jichang LiDepartment of Gastroenterology, Baoji Central Hospital, Baoji, China.
Kaiguang ZhangDepartment of Gastroenterology, Anhui Provincial Hospital, Hefei, China.
Guoliang YeDepartment of Gastroenterology, Affiliated Hospital of Ningbo University, Ningbo, China.
Liping YeDepartment of Gastroenterology, Taizhou Hospital, Taizhou, China.
Nonghua LvDepartment of Gastroenterology, First Affiliated Hospital of Nanchang University, NanChang, China.
Shengsheng ZhangDepartment of Gastroenterology, Beijing Traditional Chinese Medicine Hospital of Capital Medical University, Beijing, China.
Chengxia LiuDepartment of Gastroenterology, Affiliated Hospital of Binzhou Medical College, Binzhou, China.
Mingquan LiDepartment of Gastroenterology, Yan'an People's Hospital, Yan'an, China.
Qi LiuDepartment of Gastroenterology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Rongzhou LiDepartment of Gastroenterology, Ruian People's Hospital, Rui'an, China.
Jie PanDepartment of Gastroenterology, Wenzhou Central Hospital, Wenzhou, China.
Xiaocui YangDepartment of Gastroenterology, Ankang Central Hospital, Ankang, China.
Xuqing ZhuDepartment of Gastroenterology, Taizhou Municipal Hospital, Taizhou, China.
Yumei LiDepartment of Gastroenterology, Zhejiang General Team Hospital of Chinese People's Armed Police Force, Hangzhou, China.
Bo LaoDepartment of Gastroenterology, Ningbo Yinzhou District Second Hospital, Ningbo, China.
Ansheng LingDepartment of Gastroenterology, Anqing First People's Hospital, Anqing, China.
Honghui ChenDepartment of Gastroenterology, Second Affiliated Hospital of South China University, Hengyang, China.
Xiuling LiDepartment of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, China.
Ping XuDepartment of Gastroenterology, Shanghai Songjiang Distict Central Hospital, Shanghai, China.
Jianfeng ZhouDepartment of Gastroenterology, Ningbo Beilun District Xiaogang Hospital, Ningbo, China.
Baozhen LiuDepartment of Gastroenterology, Binzhou People's Hospital, Binzhou, China.
Zhiqiang DuDepartment of Gastroenterology, Jianyang People's Hospital, Jianyang, China.
Yiqi DuDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.ORCID 0000-0002-4261-6888
Zhaoshen LiDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Gastrointestinal Early Cancer Prevention & Treatment Alliance of China (GECA)
Second Military Medical University · CNWenzhou Medical University · CNAnhui Provincial Hospital · CNAnkang City Central Hospital · CNAnqing City Hospital · CNBaoding People's Hospital · CNBaoji City Central Hospital · CNBinzhou Medical University · CNBinzhou People's Hospital · CNCapital Medical University · CNChina Medical University · CNChinese People's Armed Police ForceFuyang City People's Hospital · CNGuiyang Medical University · CNHenan Provincial People's Hospital · CNMianyang Central Hospital · CNNanchang University · CNNingbo No. 2 Hospital · CNNingbo University Affiliated Hospital · CNSongjiang District Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo develop a gastric cancer (GC) risk prediction rule as an initial prescreening tool to identify individuals with a high risk prior to gastroscopy.

designThis was a nationwide multicentre cross-sectional study. Individuals aged 40-80 years who went to hospitals for a GC screening gastroscopy were recruited. Serum pepsinogen (PG) I, PG II, gastrin-17 (G-17) and anti-

resultsThe novel GC risk prediction rule comprised seven variables (age, sex, PG I/II ratio, G-17 level,

conclusionsThe developed and validated prediction rule showed good performance on identifying individuals at a higher risk in a Chinese high-risk population. Future studies are needed to validate its efficacy in a larger population.

Indexed as

AdultAgedAged, 80 and overAntibodies, BacterialBiomarkers, TumorDietEarly Detection of CancerFemaleGastrinsGastroscopyHelicobacter InfectionsHelicobacter pyloriHumansMaleMass ScreeningMiddle AgedAntibodies, BacterialBiomarkers, Tumorgastrin 17GastrinsPepsinogen APepsinogen Cgastric cancergastrin-17Helicobacter pyloripepsinogenprescreeningrisk stratification

Identifiers

PMID30926654
PMCPMC6709770
OpenAlexW2927994835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.