Evidence map›Paper›PMID 30926626›Full record

ArticleJournal of lipid research2019

New fluorogenic probes for neutral and alkaline ceramidases.

Mireia Casasampere, Núria Bielsa, Daniel Riba, Laura Bassas, Ruijuan Xu, Cungui Mao, Gemma Fabriàs, José-Luis Abad, Antonio Delgado, Josefina Casas

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase.Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mireia CasasampereSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.
Núria BielsaSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.
Daniel RibaSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.
Laura BassasSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.
Ruijuan XuDepartment of Medicine State University of New York at Stony Brook, Stony Brook, NY 11794-8155.
Cungui MaoDepartment of Medicine State University of New York at Stony Brook, Stony Brook, NY 11794-8155.
Gemma FabriàsSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.ORCID 0000-0001-7162-3772
José-Luis AbadSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain.ORCID 0000-0002-8343-9611
Antonio DelgadoSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain delgado@rubam.net fina.casas@iqac.csic.es.ORCID 0000-0003-4586-6070
Josefina CasasSpanish National Research Council (CSIC), Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry, Research Unit on Bioactive Molecules (RUBAM), 08034 Barcelona, Spain delgado@rubam.net fina.casas@iqac.csic.es.ORCID 0000-0002-7926-5209
Consejo Superior de Investigaciones Científicas · ESState University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New fluorogenic ceramidase substrates derived from the

Indexed as

Alkaline CeramidaseCell LineCeramidesHT29 CellsHumansIntracellular Signaling Peptides and ProteinsMagnetic Resonance SpectroscopyMicrosomesMolecular StructureRNA-Binding ProteinsSphingolipidsUmbelliferones7-hydroxycoumarinACER1 protein, humanACER2 protein, humanAlkaline CeramidaseCeramidesIntracellular Signaling Peptides and ProteinsRBM14 protein, humanRBM15 protein, humanRNA-Binding ProteinsSphingolipidsUmbelliferonesceramidessphingolipidssubstrateumbelliferone

Identifiers

PMID30926626
PMCPMC6547634
OpenAlexW2935214421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.