Evidence map›Paper›PMID 30926623›Full record

ArticleJournal of cell science2019

ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis.

Abhiyan Viplav, Tanumoy Saha, Jan Huertas, Philipp Selenschik, Mirsana P Ebrahimkutty, David Grill, Julia Lehrich, Andreas Hentschel, Monika Biasizzo, Simone Mengoni and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Abhiyan ViplavDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Tanumoy SahaDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Jan HuertasDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Philipp SelenschikDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Mirsana P EbrahimkuttyDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
David GrillDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Julia LehrichInstitute of Medical Physics and Biophysics, University of Muenster, 48149 Muenster, Germany.
Andreas HentschelLeibniz-Institut für Analytische Wissenschaften, ISAS, 44139 Dortmund, Germany.
Monika BiasizzoDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Simone MengoniDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Robert AhrendsLeibniz-Institut für Analytische Wissenschaften, ISAS, 44139 Dortmund, Germany.
Volker GerkeDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Vlad CojocaruDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Jürgen KlingaufDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany.
Milos GalicDFG Cluster of Excellence 'Cells in Motion', University of Muenster, 48149 Muenster, Germany galic@uni-muenster.de.ORCID 0000-0002-4493-2542
University of Münster · DELeibniz Institute for Analytical Sciences - ISAS · DEMax Planck Institute for Molecular Biomedicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clathrin-mediated endocytosis (CME) engages over 30 proteins to secure efficient cargo and membrane uptake. While the function of most core CME components is well established, auxiliary mechanisms crucial for fine-tuning and adaptation remain largely elusive. In this study, we identify ArhGEF37, a currently uncharacterized protein, as a constituent of CME. Structure prediction together with quantitative cellular and biochemical studies present a unique BAR domain and PI(4,5)P

Indexed as

Rho Guanine Nucleotide Exchange FactorsAnimalsClathrin-Coated VesiclesDynamin IIEndocytosisHeLa CellsHumansMiceNIH 3T3 CellsDynamin IIRho Guanine Nucleotide Exchange FactorsArhGEF37BAR domainClathrin-mediated endocytosisCMEDynamin 2Endocytosis

Identifiers

PMID30926623
PMCPMC6526708
OpenAlexW2927150350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.