Evidence map›Paper›PMID 30926606›Full record

ArticleThe Journal of biological chemistry2019

Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases.

Jesús Tejero, Andrew P Hunt, Jérôme Santolini, Nicolai Lehnert, Dennis J Stuehr

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

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  12. An isoform-specific pivot modulates the electron transfer between the flavin mononucleotide and heme centers in inducible nitric oxide synthase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jesús TejeroFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and.ORCID 0000-0003-3245-9978
Andrew P Huntthe Department of Chemistry and Department of Biophysics, University of Michigan, Ann Arbor, Michigan 48109.ORCID 0000-0003-0565-9050
Jérôme SantoliniFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and.ORCID 0000-0001-8919-112X
Nicolai Lehnertthe Department of Chemistry and Department of Biophysics, University of Michigan, Ann Arbor, Michigan 48109.ORCID 0000-0002-5221-5498
Dennis J StuehrFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and stuehrd@ccf.org.
Cleveland Clinic · USUniversity of Michigan · USCleveland Foundation · US

Funding

CONTROL MECHANISMS OF THE NITRIC OXIDE SYNTHASESR01GM051491 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI STUEHR, DENNIS J · 1994 to 2016
$5.1M
NIGMS NIH HHS R01 GM051491
6 · The paper itself

Abstract

Nitric oxide (NO) synthases (NOSs) catalyze the formation of NO from l-arginine. We have shown previously that the NOS enzyme catalytic cycle involves a large number of reactions but can be characterized by a global model with three main rate-limiting steps. These are the rate of heme reduction by the flavin domain (

Indexed as

Models, ChemicalAmino Acid SubstitutionAnimalsHemeMiceMutation, MissenseNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIOxidation-ReductionRatsHemeNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IINos1 protein, ratNos2 protein, mousecomputational biologydioxygenationenzyme kineticsenzyme mechanismhemeheme proteinheme-thiolatenitric oxidenitric-oxide synthasereaction mechanismredox reactionthermodynamics

Identifiers

PMID30926606
PMCPMC6514623
OpenAlexW2927112364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.