Evidence map›Paper›PMID 30926564›Full record

ArticleFree radical biology & medicine2019

Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.

Blazej Rubis, Michal W Luczak, Casey Krawic, Anatoly Zhitkovich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Frontiers in medicine · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Nuclear and Cytoplasmic Functions of Vitamin C.Chemical research in toxicology · 2020
    Review
  7. Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Blazej RubisDepartment of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA.
Michal W LuczakDepartment of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA.
Casey KrawicDepartment of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA.
Anatoly ZhitkovichDepartment of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA. Electronic address: anatoly_zhitkovich@brown.edu.
Brown University · US

Funding

GENOTOXICITY OF CHROMIUM COMPOUNDSR01ES008786 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZHITKOVICH, ANATOLY · 1997 to 2019
$5.7M
Regulation of p53 and Checkpoint Signaling by Chromium(VI)R01ES028072 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 2018 to 2022
$1.8M
Sensitivity Mechanisms in Chromium ToxicityR01ES012915 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 2004 to 2008
$1.6M
NIEHS NIH HHS R01 ES008786NIEHS NIH HHS R01 ES012915NIEHS NIH HHS R01 ES028072
6 · The paper itself

Abstract

Bleomycin is a redox-active drug with anticancer and other clinical applications. It is also frequently used as a tool in fundamental research on cellular responses to DNA double-strand breaks (DSBs). A conversion of bleomycin into its DNA-breaking form requires Fe, one-electron donors and O

Indexed as

Antibiotics, AntineoplasticAscorbic AcidAtaxia Telangiectasia Mutated ProteinsBleomycinCell Line, TumorDNA Breaks, Double-StrandedDNA DamageEnzyme ActivationHumansAntibiotics, AntineoplasticAscorbic AcidAtaxia Telangiectasia Mutated ProteinsATM protein, humanBleomycinAscorbateATMBleomycinDNA double-strand breakSuperoxideVitamin C

Identifiers

PMID30926564
PMCPMC6488359
OpenAlexW2923610295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.