ArticleNeuroscience2019
Pubertal hormones mediate sex differences in levels of myelin basic protein in the orbitofrontal cortex of adult rats.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Chronic exposure to LED lighting impairs prefrontal cortex-dependent cognitive functions in adolescent rats.Scientific reports · 2026Article
- Not just neurons: glial mechanisms driving sex-specific vulnerability to withdrawal and relapse in substance use disorder.Frontiers in neuroendocrinology · 2026Review
- The Left-Hand 2D:4D Ratio is Superior to the Right-Hand 2D:4D Ratio in Determining the Criminal Potential of Schizophrenia Patients.Alpha psychiatry · 2025Article
- Behavioral and transcriptional effects of age in HbSS-BERK humanized SCD mice.Journal of sickle cell disease · 2025Article
- Relating sex-bias in human cortical and hippocampal microstructure to sex hormones.Nature communications · 2024Article
- Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.Cell death discovery · 2024Article
- Consequences of oxygen deprivation on myelination and sex-dependent alterations.Molecular and cellular neurosciences · 2023Review
- Article
- Sex, myelin, and clinical characteristics of Parkinson's disease.Frontiers in neuroscience · 2023Article
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Chronic oligodendrocyte injury in central nervous system pathologies.Communications biology · 2022Review
- Different from the Beginning: WM Maturity of Female and Male Extremely Preterm Neonates-A Quantitative MRI Study.AJNR. American journal of neuroradiology · 2022Article
- Impact of Adolescent Intermittent Ethanol Exposure on Social Investigation, Social Preference, and Neuronal Activation in cFos-LacZ Male and Female Rats.Frontiers in pharmacology · 2022Article
- Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal.Neuropharmacology · 2021Article
- Impact of gonadectomy on maturational changes in brain volume in adolescent macaques.Psychoneuroendocrinology · 2021Article
- Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex differences in impulsivity in adult rats are mediated by organizational actions of neonatal gonadal hormones and not by hormones acting at puberty or in adulthood.Behavioural brain research · 2020Article
- Schizophrenia and Sex Hormones: What Is the Link?Frontiers in psychiatry · 2020Review
- Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous work from our lab revealed that adult female rats have increased levels of myelin basic protein (MBP), a marker for myelination, in the orbitofrontal cortex (OFC) as compared to adult males. The goal of the present study was to determine the role of gonadal hormones, acting either in adulthood or at puberty, in the development of an adult sex difference in OFC levels of MBP. In an initial experiment, we replicated our previous results demonstrating that gonadally intact female rats have increased levels of MBP in the OFC as compared to males. In a second experiment, gonadectomy in adulthood did not alter MBP levels in rats of either sex. In a third experiment, gonadectomy immediately prior to pubertal onset resulted in significant reduction of levels of MBP in adult females but not males. This reduction eliminated the sex difference in adult MBP levels in the OFC. These results reveal puberty to be an organizational time point for a sex difference in the OFC of adult rats in levels of a marker of myelination. This neuroanatomical difference may contribute to observed sex differences in OFC-associated behaviors including in inhibitory control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.