Evidence map›Paper›PMID 30925917›Full record

ReviewMolecular cancer2019

Mechanisms associated with biogenesis of exosomes in cancer.

Kathleen M McAndrews, Raghu Kalluri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 1 synthesis or guideline pooled it.

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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kathleen M McAndrewsDepartment of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA. kmmcandrews@mdanderson.org.ORCID 0000-0002-4092-4991
Raghu KalluriDepartment of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA. rkalluri@mdanderson.org.

Funding

The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7M
Exosomes in Cancer TherapyR01CA213233 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU · 2017 to 2021
$2.0M
NCI NIH HHS P01 CA117969NCI NIH HHS R01 CA213233
6 · The paper itself

Abstract

Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.

Indexed as

Cell CommunicationAnimalsCell MembraneExosomesHumansNeoplasmsSignal TransductionBiogenesisCancerExosomes

Identifiers

PMID30925917
PMCPMC6441149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.