Evidence map›Paper›PMID 30925893›Full record

ArticleMolecular brain2019

Conditioned stimulus presentations alter anxiety level in fear-conditioned mice.

Yujie Zhang, Kunfu Ouyang, Tatiana V Lipina, Hong Wang, Qiang Zhou

Abstract read
In one paragraph

Article in Molecular brain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. A venom fraction from the Philippine tarantula (The journal of venomous animals and toxins including tropical diseases · 2026
    Article
  3. The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Article
  5. Involvement of PKMζ in Stress Response and Depression.Frontiers in cellular neuroscience · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Analysis of memory modulation by conditioned stimuli.Learning & memory (Cold Spring Harbor, N.Y.) · 2021
    Article
  11. Linking Social Cognition to Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yujie ZhangState key laboratory of chemical oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
Kunfu OuyangState key laboratory of chemical oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
Tatiana V LipinaFederal State Budgetary Scientific Institution, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
Hong WangState key laboratory of chemical oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
Qiang ZhouState key laboratory of chemical oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China. zhouqiang.sz@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is generally believed that fear is rapidly triggered by a distinct cue while anxiety onset is less precise and not associated with a distinct cue. Although it has been claimed that both processes can be measured with certain independence of each other, it is unclear how exactly they differ. In this study, we measured anxiety in mice that received discriminative fear conditioning using behavioral, heart rate and calcium (Ca

Indexed as

AnimalsAnxietyCalciumCell-Penetrating PeptidesConditioning, ClassicalDiazepamDiscrimination, PsychologicalFearFreezing Reaction, CatalepticHeart RateHypothalamusLipopeptidesMaleMice, Inbred C57BLNeuronsProtein Kinase CCalciumCell-Penetrating PeptidesDiazepamLipopeptidesProtein Kinase CProtein Kinase C zetazeta-inhibitory peptideAmygdalaCalcium imagingDiazepamDiscriminative fear conditioningHeart ratePKMzetaVentral hippocampal CA1

Identifiers

PMID30925893
PMCPMC6441152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.