ReviewNutrients2019
Lactose Intolerance and Bone Health: The Challenge of Ensuring Adequate Calcium Intake.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- A systematic review and meta-analysis of diet and nutrient intake in adults with irritable bowel syndrome.Neurogastroenterology and motility · 2024Pooled it
- Effects of Prebiotic and Probiotic Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic Review of Controlled Trials.Nutrients · 2020Pooled it
- Efficacy of a Naturally Calcium and Magnesium-Rich Mineral Water on Musculoskeletal Fragility: A Randomized, Double-Blind Controlled Trial.Nutrients · 2026Trial
- Trial
- Trial
- [Efficacy and safety of lactase additive in preterm infants with lactose intolerance: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- Observational
- Multilevel, Actionable Factors Related to Adolescent Dairy Intake: A Scoping Review Guided by the Social Ecological Model.Current developments in nutrition · 2026Review
- Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.Antonie van Leeuwenhoek · 2026Review
- Self-reported lactose intolerance is inversely associated with calcium intake and bone mineral density: a cross-sectional data analysis from the Iwaki Health Promotion Project.European journal of nutrition · 2025Observational
- Association between calcium intake and risk of congestive heart failure: a cross-sectional study from the 2003-2018 NHANES database.BMC cardiovascular disorders · 2025Article
- Predictors of maternal hypocalcemia among pregnant women attending at a tertiary referral hospital in Tanzania: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Strategies for preventing bone loss in populations with insufficient calcium and vitamin D intake.Nutrition research and practice · 2025Review
- Association between long-term exercise with different osteogenic index, dietary patterns, body composition, biological factors, and bone mineral density in female elite masters athletes.Scientific reports · 2025Article
- Fractures in Hereditary Neuromuscular Disorders: Frequency, Risk Factors, and Implications.European journal of neurology · 2025Article
- Development and evaluation of interpretable machine learning regressors for predicting femoral neck bone mineral density in elderly men using NHANES data.Biomolecules & biomedicine · 2025Article
- Nutritional management for breast cancer patients.Ewha medical journal · 2025Review
- Genetic analysis of congenital and adult-onset lactose intolerance points to anti-inflammatory effects of dairy products.BMJ nutrition, prevention & health · 2025Article
- Novel peptides with calcium-binding capacity from antler bone hydrolysate, its bioactivity on MC3T3-E1 cells, and the possible chelating mode.Food science & nutrition · 2024Article
- From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches.Biomedicines · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium is an important nutrient with impact upon many biological systems, most notably bone. Ensuring adequate calcium intake throughout the lifespan is essential to building and maintaining bone. Lactose intolerance may predispose individuals to low calcium intake as the number of lactose-free, calcium-rich food sources is limited. In this review, we summarize data from human and animal studies on the influence of lactose and lactase deficiency on calcium absorption and bone health. Based on the available evidence, neither dietary lactose nor lactase deficiency have a significant impact on calcium absorption in adult humans. However, lactose intolerance may lead to reduced bone density and fragility fractures when accompanied by decreased intake or avoidance of dairy. Recently published human trials and meta-analyses suggest a weak but significant association between dairy consumption and bone health, particularly in children. Given the availability of simple dietary approaches to building lactose tolerance and the nutritional deficiencies associated with dairy avoidance, multiple public health organizations recommend that all individuals-including those that are lactose intolerant-consume three servings of dairy per day to ensure adequate nutrient intakes and optimal bone health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.